Salmonella immunotherapy engineered with highly efficient tumor antigen coating establishes antigen-specific CD8+ T cell immunity and increases in antitumor efficacy with type I interferon combination therapy

Salmonella immunotherapy engineered with highly efficient tumor antigen coating establishes antigen-specific CD8+ T cell immunity and increases in antitumor efficacy with type I interferon combination therapy

Bacteria-based cancer therapy employs various strategies to combat tumors, one of which is delivering tumor-associated antigen (TAA) to generate specific immunity. Here, we utilized a poly-arginine extended HPV E7 antigen (9RE7) for attachment on Salmonella SL7207 outer membrane to synthesize the ba...

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Bibliographic Details
Main Authors: Suyang Wang, Michelle Cheng, Chao-Cheng Chen, Chia-Yu Chang, Ya-Chea Tsai, Jr-Ming Yang, TC Wu, Chuan-Hsiang Huang, Chien-Fu Hung
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:OncoImmunology
Subjects:
Bacterial immunotherapy
CD8+ T cell
Cell penetrating peptide
Cervical cancer
Salmonella
Tumor antigen
Online Access:https://www.tandfonline.com/doi/10.1080/2162402X.2023.2298444
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https://www.tandfonline.com/doi/10.1080/2162402X.2023.2298444

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