Exploring the link between dietary inflammatory index and NAFLD through a structural equation modeling approach
Abstract Nonalcoholic fatty liver disease (NAFLD) or metabolic dysfunction–associated steatotic liver disease (MASLD) is a significant global public health dilemma with wide-ranging social and economic implications. Diet and lifestyle modifications remain essential components of NAFLD management. Th...
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| Language: | English |
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BMC
2024-12-01
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| Series: | Journal of Health, Population and Nutrition |
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| Online Access: | https://doi.org/10.1186/s41043-024-00721-1 |
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| author | Azam Doustmohammadian Farhad Zamani James R. Hébert Maziar Moradi-Lakeh Sepideh Esfandyiari Bahareh Amirkalali Nima Motamed Mansooreh Maadi Sherry Price Esmaeel Gholizadeh Hossein Ajdarkosh |
| author_facet | Azam Doustmohammadian Farhad Zamani James R. Hébert Maziar Moradi-Lakeh Sepideh Esfandyiari Bahareh Amirkalali Nima Motamed Mansooreh Maadi Sherry Price Esmaeel Gholizadeh Hossein Ajdarkosh |
| author_sort | Azam Doustmohammadian |
| collection | DOAJ |
| description | Abstract Nonalcoholic fatty liver disease (NAFLD) or metabolic dysfunction–associated steatotic liver disease (MASLD) is a significant global public health dilemma with wide-ranging social and economic implications. Diet and lifestyle modifications remain essential components of NAFLD management. The current study investigated the association between diet-related inflammation and NAFLD among 3110 Iranian adults participating in the Amol Cohort Study (AmolCS), employing the Structural Equation Modeling (SEM) approach.The inflammatory potential of the diet was quantified using an energy-adjusted dietary index (E-DII) score. Findings showed that in the total sample and separately in males, the E-DII score had a significant effect on NAFLD, with mediation through hypertension (βstandardized = 0.16, and 0.13, p < 0.001, respectively) and c-reactive protein (CRP) (βstandardized = 0.07, and 0.07, p < 0.001, respectively). In the total sample and separately in females, the E-DII score significantly affected NAFLD, with mediation through diabetes (βstandardized = 0.06, p < 0.001, and 0.07, p = 0.006, respectively). In full and both gender-specific models, dyslipidemia was a risk factor for NAFLD and partially mediated the effect of hypertension on NAFLD. The current study concluded a mediated association between dietary inflammation and NAFLD through hypertension, CRP, diabetes, and dyslipidemia, suggesting further longitudinal studies, especially in high-risk populations. These findings underscore the complex interplay between diet, inflammation, and NAFLD in Iranian adults. |
| format | Article |
| id | doaj-art-7cccea56c35d42088420b19692c9ab50 |
| institution | Kabale University |
| issn | 2072-1315 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Health, Population and Nutrition |
| spelling | doaj-art-7cccea56c35d42088420b19692c9ab502024-12-29T12:37:03ZengBMCJournal of Health, Population and Nutrition2072-13152024-12-0143111010.1186/s41043-024-00721-1Exploring the link between dietary inflammatory index and NAFLD through a structural equation modeling approachAzam Doustmohammadian0Farhad Zamani1James R. Hébert2Maziar Moradi-Lakeh3Sepideh Esfandyiari4Bahareh Amirkalali5Nima Motamed6Mansooreh Maadi7Sherry Price8Esmaeel Gholizadeh9Hossein Ajdarkosh10Gastrointestinal and Liver Diseases Research Center, Iran University of Medical SciencesGastrointestinal and Liver Diseases Research Center, Iran University of Medical SciencesCancer Prevention & Control Program, University of South CarolinaPreventive Medicine and Public Health Research Center, Psychosocial Health Research Institute, University of Medical SciencesDepartment of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical SciencesGastrointestinal and Liver Diseases Research Center, Iran University of Medical SciencesDepartment of Social Medicine, Zanjan University of Medical SciencesGastrointestinal and Liver Diseases Research Center, Iran University of Medical SciencesCancer Prevention & Control Program, University of South CarolinaGastrointestinal and Liver Diseases Research Center, Iran University of Medical SciencesGastrointestinal and Liver Diseases Research Center, Iran University of Medical SciencesAbstract Nonalcoholic fatty liver disease (NAFLD) or metabolic dysfunction–associated steatotic liver disease (MASLD) is a significant global public health dilemma with wide-ranging social and economic implications. Diet and lifestyle modifications remain essential components of NAFLD management. The current study investigated the association between diet-related inflammation and NAFLD among 3110 Iranian adults participating in the Amol Cohort Study (AmolCS), employing the Structural Equation Modeling (SEM) approach.The inflammatory potential of the diet was quantified using an energy-adjusted dietary index (E-DII) score. Findings showed that in the total sample and separately in males, the E-DII score had a significant effect on NAFLD, with mediation through hypertension (βstandardized = 0.16, and 0.13, p < 0.001, respectively) and c-reactive protein (CRP) (βstandardized = 0.07, and 0.07, p < 0.001, respectively). In the total sample and separately in females, the E-DII score significantly affected NAFLD, with mediation through diabetes (βstandardized = 0.06, p < 0.001, and 0.07, p = 0.006, respectively). In full and both gender-specific models, dyslipidemia was a risk factor for NAFLD and partially mediated the effect of hypertension on NAFLD. The current study concluded a mediated association between dietary inflammation and NAFLD through hypertension, CRP, diabetes, and dyslipidemia, suggesting further longitudinal studies, especially in high-risk populations. These findings underscore the complex interplay between diet, inflammation, and NAFLD in Iranian adults.https://doi.org/10.1186/s41043-024-00721-1DietDietary inflammatory indexNAFLDStructural equation modelingIranian cohort |
| spellingShingle | Azam Doustmohammadian Farhad Zamani James R. Hébert Maziar Moradi-Lakeh Sepideh Esfandyiari Bahareh Amirkalali Nima Motamed Mansooreh Maadi Sherry Price Esmaeel Gholizadeh Hossein Ajdarkosh Exploring the link between dietary inflammatory index and NAFLD through a structural equation modeling approach Journal of Health, Population and Nutrition Diet Dietary inflammatory index NAFLD Structural equation modeling Iranian cohort |
| title | Exploring the link between dietary inflammatory index and NAFLD through a structural equation modeling approach |
| title_full | Exploring the link between dietary inflammatory index and NAFLD through a structural equation modeling approach |
| title_fullStr | Exploring the link between dietary inflammatory index and NAFLD through a structural equation modeling approach |
| title_full_unstemmed | Exploring the link between dietary inflammatory index and NAFLD through a structural equation modeling approach |
| title_short | Exploring the link between dietary inflammatory index and NAFLD through a structural equation modeling approach |
| title_sort | exploring the link between dietary inflammatory index and nafld through a structural equation modeling approach |
| topic | Diet Dietary inflammatory index NAFLD Structural equation modeling Iranian cohort |
| url | https://doi.org/10.1186/s41043-024-00721-1 |
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