A new class of capsid-targeting inhibitors that specifically block HIV-1 nuclear import

A new class of capsid-targeting inhibitors that specifically block HIV-1 nuclear import

Abstract HIV-1 capsids cross nuclear pore complexes (NPCs) by engaging with the nuclear import machinery. To identify compounds that inhibit HIV-1 nuclear import, we screened drugs in silico on a three-dimensional model of a CA hexamer bound by Transportin-1 (TRN-1). Among hits, compound H27 inhibit...

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Bibliographic Details
Main Authors: Aude Boulay, Emmanuel Quevarec, Isabelle Malet, Giuseppe Nicastro, Célia Chamontin, Suzon Perrin, Corinne Henriquet, Martine Pugnière, Valérie Courgnaud, Mickaël Blaise, Anne-Geneviève Marcelin, Ian A Taylor, Laurent Chaloin, Nathalie J Arhel
Format: Article
Language:English
Published: Springer Nature 2024-10-01
Series:EMBO Molecular Medicine
Subjects:
HIV-1
Capsid
Nuclear Import
Drug Discovery
Antiretroviral Therapy
Online Access:https://doi.org/10.1038/s44321-024-00143-w
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https://doi.org/10.1038/s44321-024-00143-w

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