MSCs-derived HGF alleviates senescence by inhibiting unopposed mitochondrial fusion-based elongation in post-acute kidney injury

MSCs-derived HGF alleviates senescence by inhibiting unopposed mitochondrial fusion-based elongation in post-acute kidney injury

Abstract Background The underlying mechanism of human umbilical-derived mesenchymal stem cells (hUC-MSCs) therapy for renal senescence in post-acute kidney injury (post-AKI) remains unclear. Unopposed mitochondrial fusion-based mitochondrial elongation is required for cellular senescence. This study...

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Bibliographic Details
Main Authors:	Kaiting Zhuang, Wenjuan Wang, Xumin Zheng, Xinru Guo, Cheng Xu, Xuejing Ren, Wanjun Shen, Qiuxia Han, Zhe Feng, Xiangmei Chen, Guangyan Cai
Format:	Article
Language:	English
Published:	BMC 2024-11-01
Series:	Stem Cell Research & Therapy
Subjects:	Renal premature senescence Mesenchymal stem cells (MSCs) Hepatocyte growth factor (HGF) Mitochondrial elongation
Online Access:	https://doi.org/10.1186/s13287-024-04041-3
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