MSCs-derived HGF alleviates senescence by inhibiting unopposed mitochondrial fusion-based elongation in post-acute kidney injury

MSCs-derived HGF alleviates senescence by inhibiting unopposed mitochondrial fusion-based elongation in post-acute kidney injury

Abstract Background The underlying mechanism of human umbilical-derived mesenchymal stem cells (hUC-MSCs) therapy for renal senescence in post-acute kidney injury (post-AKI) remains unclear. Unopposed mitochondrial fusion-based mitochondrial elongation is required for cellular senescence. This study...

Full description

Saved in:
Bibliographic Details
Main Authors: Kaiting Zhuang, Wenjuan Wang, Xumin Zheng, Xinru Guo, Cheng Xu, Xuejing Ren, Wanjun Shen, Qiuxia Han, Zhe Feng, Xiangmei Chen, Guangyan Cai
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Stem Cell Research & Therapy
Subjects:
Renal premature senescence
Mesenchymal stem cells (MSCs)
Hepatocyte growth factor (HGF)
Mitochondrial elongation
Online Access:https://doi.org/10.1186/s13287-024-04041-3
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1186/s13287-024-04041-3

Similar Items