Combined strategy of α 9-integrin transduction and AEIDGIEL peptide-functionalized fibrin gel biomaterials to promote mature DRG neurite growth

Combined strategy of α 9-integrin transduction and AEIDGIEL peptide-functionalized fibrin gel biomaterials to promote mature DRG neurite growth

IntroductionSpinal cord injury involves complex pathobiological mechanisms, necessitating a multidimensional approach for its cure. Previous studies have shown that α9-integrin expression and activation in mature dorsal root ganglion neurons enable the regeneration of injured axons within the spinal...

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Bibliographic Details
Main Authors: Anda Cimpean, Lars Roll, Jacqueline Reinhard, Jessica C. F. Kwok, Andreas Faissner, Fred de Winter, James W. Fawcett, Pavla Jendelová
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Cellular Neuroscience
Subjects:
α9-integrin
fibrin gel
AEIDGIEL peptide
tenascin-c
dorsal root ganglion
neurite growth
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2025.1568004/full
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https://www.frontiersin.org/articles/10.3389/fncel.2025.1568004/full

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