Elimination of hepatocyte‐derived DPP4 downregulates cardiac immune‐ and collagen‐related genes but does not alter cardiac function in aged male mice

Elimination of hepatocyte‐derived DPP4 downregulates cardiac immune‐ and collagen‐related genes but does not alter cardiac function in aged male mice

Abstract The association between metabolic dysfunction–associated steatotic liver disease (MASLD) and cardiovascular disease is well characterized; however, the underlying mechanism is incompletely understood. Interestingly, hepatocyte‐specific silencing of dipeptidyl peptidase 4 (DPP4) prevents liv...

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Main Authors: Natasha A. Trzaskalski, Melissa M. Dann, Antonio Hanson, Branka Vulesevic, Evgenia Fadzeyeva, Natasha Jeraj, Ilka Lorenzen‐Schmidt, Rick Seymour, Erin E. Mulvihill
Format: Article
Language:English
Published: Wiley 2025-08-01
Series:Physiological Reports
Subjects:
cardiovascular dysfunction
diastolic dysfunction
dipeptidyl peptidase‐4
echocardiography
hepatokine
Online Access:https://doi.org/10.14814/phy2.70453
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https://doi.org/10.14814/phy2.70453

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