p62/SQSTM1 promotes rapid ubiquitin conjugation to target proteins after endosome rupture during xenophagy

p62/SQSTM1 promotes rapid ubiquitin conjugation to target proteins after endosome rupture during xenophagy

Autophagy is a bulk degradation pathway, and selective autophagy to remove foreign entities is called xenophagy. The conjugation of ubiquitin to target pathogens is an important process in xenophagy but when and where this ubiquitination occurs remains unclear. Here, we analyzed the temporal sequenc...

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Bibliographic Details
Main Authors: Megumi Tsuchiya, Hidesato Ogawa, Takako Koujin, Chie Mori, Hiroko Osakada, Shouhei Kobayashi, Yasushi Hiraoka, Tokuko Haraguchi
Format: Article
Language:English
Published: Wiley 2018-03-01
Series:FEBS Open Bio
Subjects:
artificial beads
autophagy
bacterial infection
LC3
p62
ubiquitination
Online Access:https://doi.org/10.1002/2211-5463.12385
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https://doi.org/10.1002/2211-5463.12385

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