Methotrexate Hepatotoxicity in Psoriatics: Report of 104 Patients from Nova Scotia, with Analysis of Risks from Obesity, Diabetes and Alcohol Consumption During Long Term Follow-Up
BACKGROUND AND DESIGN: Methotrexate (MTX) hepatotoxicity in psoriatic patients is well recognized, but there are discrepancies in the reported incidence and associated risk factors. This retrospective study describes 104 Nova Scotian patients with psoriasis seen between 1979 and 1990. Patients recei...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
1996-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/1996/213596 |
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| _version_ | 1841524873512353792 |
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| author | DA Malatjalian JB Ross CN Williams SJ Colwell BJ Eastwood |
| author_facet | DA Malatjalian JB Ross CN Williams SJ Colwell BJ Eastwood |
| author_sort | DA Malatjalian |
| collection | DOAJ |
| description | BACKGROUND AND DESIGN: Methotrexate (MTX) hepatotoxicity in psoriatic patients is well recognized, but there are discrepancies in the reported incidence and associated risk factors. This retrospective study describes 104 Nova Scotian patients with psoriasis seen between 1979 and 1990. Patients received MTX over one to 11 years (mean 3.38), with baseline and annual follow-up liver biopsies. Clinical data were obtained by chart review. Statistical analysis evaluated the risks associated with obesity, diabetes, alcohol consumption and duration of therapy, with the histological grade of liver biopsies. |
| format | Article |
| id | doaj-art-7b6ada2f977a452b81cdd61c007f23f8 |
| institution | Kabale University |
| issn | 0835-7900 |
| language | English |
| publishDate | 1996-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology |
| spelling | doaj-art-7b6ada2f977a452b81cdd61c007f23f82025-02-03T05:47:14ZengWileyCanadian Journal of Gastroenterology0835-79001996-01-0110636937510.1155/1996/213596Methotrexate Hepatotoxicity in Psoriatics: Report of 104 Patients from Nova Scotia, with Analysis of Risks from Obesity, Diabetes and Alcohol Consumption During Long Term Follow-UpDA Malatjalian0JB Ross1CN Williams2SJ Colwell3BJ Eastwood4Divisions of Anatomical Pathology, Dermatology, Gastroenterology, Department of Community Health and Epidemiology, Dalhousie University and Victoria General Hospital, Halifax, Nova Scotia, CanadaDivisions of Anatomical Pathology, Dermatology, Gastroenterology, Department of Community Health and Epidemiology, Dalhousie University and Victoria General Hospital, Halifax, Nova Scotia, CanadaDivisions of Anatomical Pathology, Dermatology, Gastroenterology, Department of Community Health and Epidemiology, Dalhousie University and Victoria General Hospital, Halifax, Nova Scotia, CanadaDivisions of Anatomical Pathology, Dermatology, Gastroenterology, Department of Community Health and Epidemiology, Dalhousie University and Victoria General Hospital, Halifax, Nova Scotia, CanadaDivisions of Anatomical Pathology, Dermatology, Gastroenterology, Department of Community Health and Epidemiology, Dalhousie University and Victoria General Hospital, Halifax, Nova Scotia, CanadaBACKGROUND AND DESIGN: Methotrexate (MTX) hepatotoxicity in psoriatic patients is well recognized, but there are discrepancies in the reported incidence and associated risk factors. This retrospective study describes 104 Nova Scotian patients with psoriasis seen between 1979 and 1990. Patients received MTX over one to 11 years (mean 3.38), with baseline and annual follow-up liver biopsies. Clinical data were obtained by chart review. Statistical analysis evaluated the risks associated with obesity, diabetes, alcohol consumption and duration of therapy, with the histological grade of liver biopsies.http://dx.doi.org/10.1155/1996/213596 |
| spellingShingle | DA Malatjalian JB Ross CN Williams SJ Colwell BJ Eastwood Methotrexate Hepatotoxicity in Psoriatics: Report of 104 Patients from Nova Scotia, with Analysis of Risks from Obesity, Diabetes and Alcohol Consumption During Long Term Follow-Up Canadian Journal of Gastroenterology |
| title | Methotrexate Hepatotoxicity in Psoriatics: Report of 104 Patients from Nova Scotia, with Analysis of Risks from Obesity, Diabetes and Alcohol Consumption During Long Term Follow-Up |
| title_full | Methotrexate Hepatotoxicity in Psoriatics: Report of 104 Patients from Nova Scotia, with Analysis of Risks from Obesity, Diabetes and Alcohol Consumption During Long Term Follow-Up |
| title_fullStr | Methotrexate Hepatotoxicity in Psoriatics: Report of 104 Patients from Nova Scotia, with Analysis of Risks from Obesity, Diabetes and Alcohol Consumption During Long Term Follow-Up |
| title_full_unstemmed | Methotrexate Hepatotoxicity in Psoriatics: Report of 104 Patients from Nova Scotia, with Analysis of Risks from Obesity, Diabetes and Alcohol Consumption During Long Term Follow-Up |
| title_short | Methotrexate Hepatotoxicity in Psoriatics: Report of 104 Patients from Nova Scotia, with Analysis of Risks from Obesity, Diabetes and Alcohol Consumption During Long Term Follow-Up |
| title_sort | methotrexate hepatotoxicity in psoriatics report of 104 patients from nova scotia with analysis of risks from obesity diabetes and alcohol consumption during long term follow up |
| url | http://dx.doi.org/10.1155/1996/213596 |
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