CCR2 Regulates Referred Somatic Hyperalgesia by Mediating T-Type Ca<sup>2+</sup> Channel Currents of Small-Diameter DRG Neurons in Gastric Ulcer Mice

CCR2 Regulates Referred Somatic Hyperalgesia by Mediating T-Type Ca<sup>2+</sup> Channel Currents of Small-Diameter DRG Neurons in Gastric Ulcer Mice

<b>Background</b>: Referred pain frequently co-exists with visceral pain. However, the exact mechanism governing referred somatic hyperalgesia remains elusive. <b>Methods</b>: By injecting 20% acetic acid into the stomach, we established a mouse model of gastric ulcer (GU). H...

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Bibliographic Details
Main Authors: Ziyan Yuan, Huanhuan Liu, Zhijun Diao, Wei Yuan, Yuwei Wu, Simeng Xue, Xinyan Gao, Haifa Qiao
Format: Article
Language:English
Published: MDPI AG 2025-02-01
Series:Brain Sciences
Subjects:
referred somatic hyperalgesia
dorsal root ganglion
T-type Ca<sup>2+</sup> channels
the C-C motif chemokine receptor 2
Gastric ulcer
Online Access:https://www.mdpi.com/2076-3425/15/3/255
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