Development of a novel intramuscular liposomal injection for advanced meloxicam delivery: Preparation, characterization, in vivo pharmacokinetics, pharmacodynamics, and pain assessment in an orthopedic pain model

Development of a novel intramuscular liposomal injection for advanced meloxicam delivery: Preparation, characterization, in vivo pharmacokinetics, pharmacodynamics, and pain assessment in an orthopedic pain model

Pain produces several physiological, and degenerative complications. This study aimed to formulate meloxicam (MLX) in liposomes to increase solubility and deliver MLX in a controlled manner to overcome its poor aqueous solubility and relatively short t1/2 problems. Liposomes were prepared by thin fi...

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Bibliographic Details
Main Authors: Pierre A. Hanna, Hatim A. Al-Abbadi, Mohamed A. Hashem, Aziza E. Mostafa, Yasmina K. Mahmoud, Eman A. Ahmed, Ibrahim M. Hegab, Ibrahim E. Helal, Mahmoud F. Ahmed
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:International Journal of Pharmaceutics: X
Subjects:
Meloxicam
Liposomes
Pain management
Pharmacokinetics
Interleukin-6
CMPS-SF pain scale
Online Access:http://www.sciencedirect.com/science/article/pii/S2590156724000562
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