Multi-scale and multi-context interpretable mapping of cell states across heterogeneous spatial samples

Abstract There is a growing demand for methods that can effectively align and compare spatial data in the absence of obvious visual correspondence. To address this challenge, we developed an interpretable cell mapping strategy based on solving a Linear Assignment Problem (LAP) where the total cost i...

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Bibliographic Details
Main Authors: Patrick C. N. Martin, Wenqi Wang, Hyobin Kim, Henrietta Holze, Paul B. Fisher, Arturo P. Saavedra, Robert A. Winn, Esha Madan, Rajan Gogna, Kyoung Jae Won
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-62782-y
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