Experience-dependent maternal defense behavior mediated by profrontal cortical projections to the medial preoptic area in mice

Abstract Maternal defense, a hallmark of motherhood, often involves protecting offspring at personal risk. However, the neural mechanisms underlying the emergence and modulation of this behavior remain not-well understood. Here, we introduce a novel paradigm in which mother mice under threat priorit...

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Bibliographic Details
Main Authors: Kaibin Wu, Peiwen Tang, Yuwei Wang, Fangcai Mai, Yidi Pan, Li I. Zhang, Huizhong W. Tao, Feixue Liang
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-63062-5
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