Ketoacidosis as unexpected adverse reaction SGLT<sub>2</sub> inhibitor

Ketoacidosis as unexpected adverse reaction SGLT<sub>2</sub> inhibitor

Inhibitors of the sodium-glucose cotransporter-2 SGLT2 is a new class of hypoglycemic drugs. This article presents the information on FDA reports (2013-2015) and AIS (May 2015 - February 2016) on the risk of new adverse reaction - ketoacidosis. Conjectural pathophysiological mechanisms of ADR associ...

Full description

Saved in:

Bibliographic Details
Main Authors:	T. M. Bukatina, A. S. Kazakov, N. Yu. Velts, M. A. Darmostukova, K. E. Zatolochina, R. N. Alyautdin, V. P. Dobrynin, B. K. Romanov
Format:	Article
Language:	Russian
Published:	Ministry of Health of the Russian Federation, Federal State Budgetary Institution «Scientific Centre for Expert Evaluation of Medicinal Products» 2018-02-01
Series:	Безопасность и риск фармакотерапии
Subjects:	ингибиторы sglt<sub>2</sub> кетоацидоз сахарный диабет 2 типа дапаглифлозин inhibitors of sglt2 ketoacidosis type 2 diabetes dapagliflozin
Online Access:	https://www.risksafety.ru/jour/article/view/58
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

EVALUAREA EFICACITĂȚII TERAPIEI CU INHIBITORI SGLT2 LA PACIENȚII CU INSUFICIENȚĂ CARDIACĂ CU FRACȚIE DE EJECȚIE PĂSTRATĂ
by: Tatiana Cotonet, et al.
Published: (2025-03-01)

Impact of SGLT2 inhibitors on myocardial fibrosis in diabetic HFpEF: a longitudinal study
by: Arif Albulushi, et al.
Published: (2025-07-01)

Perioperative prevention of euglycaemic diabetic ketoacidosis in people living with type 2 diabetes established on sodium-glucose transport-2 inhibitors – a cross-site multi-cycle audit
by: Karl A. Romain, et al.
Published: (2025-09-01)

SGLT2 Inhibitors and genital infections: a prospective observational study in a tertiary care hospital
by: Numan Malik, et al.
Published: (2025-07-01)

SGLT2 Inhibitors in Patients with Chronic Kidney Disease and Heart Disease: A Literature Review
by: Abhishek Kansara, et al.
Published: (2022-09-01)

Effects of Sodium–Glucose Cotransporter 2 Inhibitors on Calcium Homeostasis: Where We Stand Now
by: Alessandro Cuttone, et al.
Published: (2025-05-01)

Towards quadruple therapy for heart failure with reduced ejection fraction: DAPA-HF secondary analysis data
by: Zh. D. Kobalava, et al.
Published: (2020-06-01)

Prevalence and thrombotic risk of SGLT-2 inhibitor-associated erythrocytosis: a retrospective cohort study
by: Ji Yun Lee, et al.
Published: (2025-07-01)

Randomized, Placebo-Controlled Trial on the Renal and Systemic Hemodynamic Effects of Empagliflozin
by: Steffen Flindt Nielsen, et al.
Published: (2025-01-01)

Development of an Efficient Process for a Key Synthetic Intermediate of the SGLT2 Inhibitor LH-1801
by: Jun Qu, et al.

Canagliflozin: from glycemic control to improvement of cardiovascular and renal prognosis in patients with type 2 diabetes mellitus. Resolution of Advisory Board
by: M. V. Shestakova, et al.
Published: (2022-01-01)

An Investigation of WO<sub>3</sub>/V<sub>2</sub>O<sub>5</sub>/TiO<sub>2</sub> Catalysts: Effects of WO<sub>3</sub> on Morphology, Thermal Stability, and Activity for the Catalytic Oxidation of Dimethyl Sulfide
by: Gaytri Sharma, et al.
Published: (2025-06-01)

SGLT2 inhibition mitigates intracerebral hemorrhage risk by modulating inflammation
by: Mingsheng Huang, et al.
Published: (2025-05-01)

The effects of SGLT2i on cardiac metabolism in patients with HFpEF: Fact or fiction?
by: Francesca Cinti, et al.
Published: (2025-05-01)

SGLT2-inhibition and myocardial infarction size in patients with type 2 diabetes mellitus– Insights from an acute cardiovascular care center
by: Istvan Bojti, et al.
Published: (2025-08-01)

Erythrocytosis incidence and thromboembolic risk in heart failure with reduced ejection fraction treated with SGLT2 inhibitors: a nationwide register-based cohort study
by: Abdullahi Ahmed Mohamed, et al.
Published: (2025-08-01)

Position of SGLT2i in prediabetes: A systematic review of literature
by: Kaushik Biswas, et al.
Published: (2025-04-01)

Evolution of CHA<sub>2</sub>DS<sub>2</sub>-VASc Score for Predicting Risk of Stroke Development in Patients with Atrial Fibrillation
by: A. O. Rubanenko
Published: (2023-05-01)

Preparation of CdIn<sub>2</sub>S<sub>4</sub>/TiO<sub>2</sub> Nanocomposites and Its Photocathodic Protection Properties for Q235 Carbon Steel
by: SONG Wei - zhe, LI Hong, CUI Xing - qiang, LI Yan - hui, CHENG Lian - jun, LI Jun - ru
Published: (2021-03-01)

New Therapies on the Horizon for Preventing the Progression of Chronic Kidney Disease in Childhood
by: Siobhan Wagner, et al.
Published: (2023-12-01)

Effect of CTAB on the Morphology of Sn-MOF and the Gas Sensing Performance of SnO<sub>2</sub> with Different Crystal Phases for H<sub>2</sub> Detection
by: Manyi Liu, et al.
Published: (2025-05-01)

Nitrogen-Doped Carbon Dots as a Fluorescent “Off–On” Probe for Selective Ascorbic Acid Detection via H<sub>2</sub>O<sub>2</sub>-Mediated Quenching
by: Jingjing Jia, et al.
Published: (2025-06-01)

Study on the High-Temperature Corrosion Behavior of Cr<sub>3</sub>C<sub>2</sub>/Cr<sub>2</sub>AlC MAX Phase Composite Coatings on Stainless Steel Surfaces in Molten Sodium Polysulfide
by: CUI Xingcheng, REN Yanjie, XIAO Biao, LI Yanhua, CHEN Jian, ZHOU Libo, QIU Wei, HUANG Weiying, NIU Yan
Published: (2025-06-01)

Non-empirical calculations of minimal energetic ways of addition of H<sub>2</sub>F<sub>2</sub> and H<sub>2</sub>Cl<sub>2</sub> molecules to acetylene and methylacetylene molecules
by: Yu. B. Kirillov, et al.
Published: (2012-12-01)

Effect of Sodium-Glucose Cotransporter Type 2 Inhibitors on The Development and Course of Atrial Fibrillation
by: D. A. Ishmaev, et al.
Published: (2025-01-01)

Development and Evaluation of a CO<sub>2</sub> Capture System Using Hollow Fiber Membranes for Industrial Emissions Applications
by: Stephanie Arias-Lugo, et al.
Published: (2024-05-01)

Sravnenie nefroprotektivnykh effektov selektivnogo blokatora endotelinovykh retseptorov i ingibitora APF na modeli eksperimental'nogo sakharnogo diabeta tipa 2
by: E Fedorova, et al.
Published: (2004-03-01)

Barrier-Free Carrier Injection in 2D WSe<sub>2</sub>-MoSe<sub>2</sub> Heterostructures via Fermi-Level Depinning
by: Tian-Jun Dai, et al.
Published: (2025-07-01)

Effects of Different Y<sub>2</sub>O<sub>3</sub> Contents on the Microstructure of Ni-Based WC Ceramic Composite Coating by Laser Cladding
by: JIN Lijun, LIU Zhenzhen
Published: (2025-05-01)

Influence of Y<sub>2</sub>O<sub>3</sub> Concentration on the Optical Properties of Multicomponent Glasses and Glass–Ceramics
by: Akram Beniaiche, et al.
Published: (2024-11-01)

Preparation and Optimization of Mn<sup>2+</sup>-Activated Na<sub>2</sub>ZnGeO<sub>4</sub> Phosphors: Insights into Precursor Selection and Microwave-Assisted Solid-State Synthesis
by: Xiaomeng Wang, et al.
Published: (2025-07-01)

Role of sodium-glucose cotransporter 2 inhibitors in cardiovascular events in patients with heart failure
by: Eva Muja, et al.
Published: (2025-07-01)

Dapagliflozin prevents vascular ischemia-reperfusion injury in healthy young males: a randomized, placebo-controlled, double-blinded trial
by: Martin Lutnik, et al.
Published: (2025-05-01)

Updates on New Therapies for Patients with CKD
by: Tushar Tarun, et al.
Published: (2024-01-01)

Comparative effectiveness and safety of sodium-glucose cotransporter 2 inhibitors vs glucagon-like peptide 1 receptor agonists in elderly patients with type 2 diabetes mellitus: a meta-analysis
by: Yao Wang, et al.
Published: (2025-08-01)

The role of canagliflozin in the prevention of stroke and chronic kidney disease in patients with type 2 diabetes mellitus: an expert council resolution
by: M. V. Shestakova, et al.
Published: (2023-11-01)

Flexible Gas Sensor Based on PANI/WO<sub>3</sub>/CuO for Room-Temperature Detection of H<sub>2</sub>S
by: Dongxiang Zhang, et al.
Published: (2025-04-01)

Chiral-Dependent Redox Capacitive Biosensor Using Cu-Cys-GSH Nanoparticles for Ultrasensitive H<sub>2</sub>O<sub>2</sub> Detection
by: Duygu Yilmaz Aydin, et al.
Published: (2025-05-01)

Enhanced UVC Responsivity of Heteroepitaxial α-Ga<sub>2</sub>O<sub>3</sub> Photodetector with Ultra-Thin HfO<sub>2</sub> Interlayer
by: SiSung Yoon, et al.
Published: (2025-07-01)

A decade of progress in type 2 diabetes and cardiovascular disease: advances in SGLT2 inhibitors and GLP-1 receptor agonists – a comprehensive review
by: David Aristizábal-Colorado, et al.
Published: (2025-07-01)