Inherent stochasticity, noise and limits of detection in continuous and time-gated fluorescence systems.

We present a model for the noise and inherent stochasticity of fluorescence signals in both continuous wave (CW) and time-gated (TG) conditions. When the fluorophores are subjected to an arbitrary excitation photon flux, we apply the model and compute the evolution of the probability mass function (...

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Bibliographic Details
Main Authors: Nicholas H Vitale, Arjang Hassibi, Hyongsok Tom Soh, Boris Murmann, Thomas H Lee
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2024-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0313949
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