Value of high frame rate contrast-enhanced ultrasound in predicting microvascular invasion of hepatocellular carcinoma
Abstract Objectives To investigate the value of vascular morphology on high frame rate contrast-enhanced ultrasound (H-CEUS) and CEUS Li-RADS in predicting microvascular invasion (MVI), Ki-67 expression and recurrence of hepatocellular carcinoma (HCC). Methods This retrospective study enrolled 78 pa...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2024-11-01
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| Series: | Insights into Imaging |
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| Online Access: | https://doi.org/10.1186/s13244-024-01821-6 |
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| author | Xiang Fei Lianhua Zhu Peng Han Bo Jiang Miao Li Nan Li Ziyu Jiao Dirk-André Clevert Yukun Luo |
| author_facet | Xiang Fei Lianhua Zhu Peng Han Bo Jiang Miao Li Nan Li Ziyu Jiao Dirk-André Clevert Yukun Luo |
| author_sort | Xiang Fei |
| collection | DOAJ |
| description | Abstract Objectives To investigate the value of vascular morphology on high frame rate contrast-enhanced ultrasound (H-CEUS) and CEUS Li-RADS in predicting microvascular invasion (MVI), Ki-67 expression and recurrence of hepatocellular carcinoma (HCC). Methods This retrospective study enrolled 78 patients with single HCC diagnosed by postoperative pathology between January 1, 2021, and June 30, 2022. All patients underwent ultrasound and H-CEUS examination before operation. H-CEUS image features and CEUS Li-RADS were compared in different MVI status and Ki-67 level. Multiple logistic regression analysis was performed to select independent variables for MVI. Differences in recurrence among different H-CEUS image features, MVI status and Ki-67 level were further analyzed. Results Tumor shape, vascular morphology, LR-M category, necrosis and AFP level were different between the MVI-positive group and MVI-negative group (p < 0.05). Vascular morphology and LR-M category were independent risk factors related to MVI (p < 0.05). Vascular morphology was also different between the high Ki-67 expression group and low Ki-67 expression group (p < 0.05). Vascular morphology, MVI status and Ki-67 expression were different between the recurrence group and no recurrence group (p < 0.05). Conclusion The vascular morphology of HCC on H-CEUS can indicate the risk of MVI status, Ki-67 expression and recurrence, which provides a feasible imaging technique for predicting the prognosis before operation. Critical relevance statement H-CEUS shows the different vascular morphology of HCC in arterial phase and indicates the risk of MVI, Ki-67 expression and recurrence, which provides a feasible imaging technique for clinician to judge the risk of MVI pre-operation and adopt appropriate treatment. Key Points H-CEUS can clearly show different vascular morphology of HCC in arterial phase. Vascular morphology on H-CEUS is associated with MVI status, Ki-67 expression and HCC recurrence. Preoperative MVI and Ki-67 expression prediction could help surgeons choose a more appropriate treatment plan. Graphical Abstract |
| format | Article |
| id | doaj-art-7a0d394a99994a9d89cd9709e158e97c |
| institution | Kabale University |
| issn | 1869-4101 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Insights into Imaging |
| spelling | doaj-art-7a0d394a99994a9d89cd9709e158e97c2024-11-17T12:31:55ZengSpringerOpenInsights into Imaging1869-41012024-11-0115111210.1186/s13244-024-01821-6Value of high frame rate contrast-enhanced ultrasound in predicting microvascular invasion of hepatocellular carcinomaXiang Fei0Lianhua Zhu1Peng Han2Bo Jiang3Miao Li4Nan Li5Ziyu Jiao6Dirk-André Clevert7Yukun Luo8Department of Ultrasound, The First Medical Centre, Chinese PLA General HospitalDepartment of Ultrasound, The First Medical Centre, Chinese PLA General HospitalDepartment of Ultrasound, The First Medical Centre, Chinese PLA General HospitalDepartment of Ultrasound, The First Medical Centre, Chinese PLA General HospitalDepartment of Ultrasound, The First Medical Centre, Chinese PLA General HospitalDepartment of Ultrasound, The First Medical Centre, Chinese PLA General HospitalDepartment of Ultrasound, The First Medical Centre, Chinese PLA General HospitalInterdisciplinary Ultrasound-Center University of Munich-Grosshadern CampusDepartment of Ultrasound, The First Medical Centre, Chinese PLA General HospitalAbstract Objectives To investigate the value of vascular morphology on high frame rate contrast-enhanced ultrasound (H-CEUS) and CEUS Li-RADS in predicting microvascular invasion (MVI), Ki-67 expression and recurrence of hepatocellular carcinoma (HCC). Methods This retrospective study enrolled 78 patients with single HCC diagnosed by postoperative pathology between January 1, 2021, and June 30, 2022. All patients underwent ultrasound and H-CEUS examination before operation. H-CEUS image features and CEUS Li-RADS were compared in different MVI status and Ki-67 level. Multiple logistic regression analysis was performed to select independent variables for MVI. Differences in recurrence among different H-CEUS image features, MVI status and Ki-67 level were further analyzed. Results Tumor shape, vascular morphology, LR-M category, necrosis and AFP level were different between the MVI-positive group and MVI-negative group (p < 0.05). Vascular morphology and LR-M category were independent risk factors related to MVI (p < 0.05). Vascular morphology was also different between the high Ki-67 expression group and low Ki-67 expression group (p < 0.05). Vascular morphology, MVI status and Ki-67 expression were different between the recurrence group and no recurrence group (p < 0.05). Conclusion The vascular morphology of HCC on H-CEUS can indicate the risk of MVI status, Ki-67 expression and recurrence, which provides a feasible imaging technique for predicting the prognosis before operation. Critical relevance statement H-CEUS shows the different vascular morphology of HCC in arterial phase and indicates the risk of MVI, Ki-67 expression and recurrence, which provides a feasible imaging technique for clinician to judge the risk of MVI pre-operation and adopt appropriate treatment. Key Points H-CEUS can clearly show different vascular morphology of HCC in arterial phase. Vascular morphology on H-CEUS is associated with MVI status, Ki-67 expression and HCC recurrence. Preoperative MVI and Ki-67 expression prediction could help surgeons choose a more appropriate treatment plan. Graphical Abstracthttps://doi.org/10.1186/s13244-024-01821-6Hepatocellular carcinomaVascular morphologyHigh frame rate contrast-enhanced ultrasoundRecurrenceCEUS Li-RADS |
| spellingShingle | Xiang Fei Lianhua Zhu Peng Han Bo Jiang Miao Li Nan Li Ziyu Jiao Dirk-André Clevert Yukun Luo Value of high frame rate contrast-enhanced ultrasound in predicting microvascular invasion of hepatocellular carcinoma Insights into Imaging Hepatocellular carcinoma Vascular morphology High frame rate contrast-enhanced ultrasound Recurrence CEUS Li-RADS |
| title | Value of high frame rate contrast-enhanced ultrasound in predicting microvascular invasion of hepatocellular carcinoma |
| title_full | Value of high frame rate contrast-enhanced ultrasound in predicting microvascular invasion of hepatocellular carcinoma |
| title_fullStr | Value of high frame rate contrast-enhanced ultrasound in predicting microvascular invasion of hepatocellular carcinoma |
| title_full_unstemmed | Value of high frame rate contrast-enhanced ultrasound in predicting microvascular invasion of hepatocellular carcinoma |
| title_short | Value of high frame rate contrast-enhanced ultrasound in predicting microvascular invasion of hepatocellular carcinoma |
| title_sort | value of high frame rate contrast enhanced ultrasound in predicting microvascular invasion of hepatocellular carcinoma |
| topic | Hepatocellular carcinoma Vascular morphology High frame rate contrast-enhanced ultrasound Recurrence CEUS Li-RADS |
| url | https://doi.org/10.1186/s13244-024-01821-6 |
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