mTOR pathway targeted inhibition via Rapamycin-loaded PLGA nanoparticles for enhanced bladder cancer therapy

Abstract Bladder cancer remains a major clinical challenge due to high recurrence rates, metastatic potential, and the development of drug resistance driven by complex gene regulation. Targeting the PI3K/AKT/mTOR pathway is a promising strategy, as its dysregulation promotes tumor growth and surviva...

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Bibliographic Details
Main Authors: Nour-Elhoda El-hefnawy, Magdy M Youssef, Hassan Abol-Enein, Raghda Abo Gabal
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-025-06965-z
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