Sprouty2 Regulates Endocytosis and Degradation of Fibroblast Growth Factor Receptor 1 in Glioblastoma Cells

Sprouty2 Regulates Endocytosis and Degradation of Fibroblast Growth Factor Receptor 1 in Glioblastoma Cells

The Sprouty (SPRY) proteins are evolutionary conserved modulators of receptor tyrosine kinase (RTK) signaling. SPRY2 inhibits fibroblast growth factor (FGF) signaling, whereas it enhances epidermal growth factor (EGF) signaling through inhibition of EGF receptor (EGFR) endocytosis, ubiquitination, a...

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Bibliographic Details
Main Authors: Barbara Hausott, Lena Pircher, Michaela Kind, Jong-Whi Park, Peter Claus, Petra Obexer, Lars Klimaschewski
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Cells
Subjects:
caveolin-1
c-casitas b-lineage lymphoma
clathrin
extracellular signal-regulated kinase
phospholipase Cγ1
ubiquitin
Online Access:https://www.mdpi.com/2073-4409/13/23/1967
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