3D genomic features across >50 diverse cell types reveal insights into the genomic architecture of childhood obesity

3D genomic features across >50 diverse cell types reveal insights into the genomic architecture of childhood obesity

The prevalence of childhood obesity is increasing worldwide, along with the associated common comorbidities of type 2 diabetes and cardiovascular disease in later life. Motivated by evidence for a strong genetic component, our prior genome-wide association study (GWAS) efforts for childhood obesity...

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Main Authors: Khanh B Trang, Matthew C Pahl, James A Pippin, Chun Su, Sheridan H Littleton, Prabhat Sharma, Nikhil N Kulkarni, Louis R Ghanem, Natalie A Terry, Joan M O'Brien, Yadav Wagley, Kurt D Hankenson, Ashley Jermusyk, Jason Hoskins, Laufey T Amundadottir, Mai Xu, Kevin Brown, Stewart Anderson, Wenli Yang, Paul Titchenell, Patrick Seale, Klaus H Kaestner, Laura Cook, Megan Levings, Babette S Zemel, Alessandra Chesi, Andrew D Wells, Struan FA Grant
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-01-01
Series:eLife
Subjects:
pancreatic cells
immune cells
iPSC
hepatic cells
neurons
mesenchymal stem cells
Online Access:https://elifesciences.org/articles/95411
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https://elifesciences.org/articles/95411

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