Evaluating level of adherence to nicotine replacement therapy and its impact on smoking cessation: a protocol for systematic review and meta-analysis
Introduction Nicotine replacement therapy (NRT) has proven effective for smoking cessation in clinical trials, however it was found less effective in population-based studies, potentially due to inconsistent or incorrect use of NRT. The aim of this paper is to describe a systematic review protocol t...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMJ Publishing Group
2020-09-01
|
| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/10/9/e039775.full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841554106077937664 |
|---|---|
| author | Michelle Bovill Gillian Sandra Gould Amanual Getnet Mersha Parivash Eftekhari Daniel Nigusse Tollosa |
| author_facet | Michelle Bovill Gillian Sandra Gould Amanual Getnet Mersha Parivash Eftekhari Daniel Nigusse Tollosa |
| author_sort | Michelle Bovill |
| collection | DOAJ |
| description | Introduction Nicotine replacement therapy (NRT) has proven effective for smoking cessation in clinical trials, however it was found less effective in population-based studies, potentially due to inconsistent or incorrect use of NRT. The aim of this paper is to describe a systematic review protocol to evaluate level of adherence to NRT; the discrepancy of adherence to NRT in clinical and population-based studies and degree of association between level of adherence and success of smoking cessation.Methods and analysis Literature search will use five databases (Medline, Scopus, Embase, CINAHL and PsycINFO). Studies will be appraised for methodological quality using National Institutes of Health Quality Assessment Tool. To reduce heterogeneity, we will analyse clinical trials and population-based studies separately; pooled analyses will be done among studies that used similar measurements. Heterogeneity of studies will be assessed by Higgins’ I2 statistical test. When studies are adequately homogeneous, results will be pooled using random-effects model with proportion and ORs with 95% CIs and p values for each outcome. We will explain sources of heterogeneity by subgroup analysis or sensitivity analysis. Funnel plots and Egger’s regression asymmetry test with p<0.05 will be used as a cut-off point to affirm presence of statistically significant publication bias. Statistical analyses will be carried out using Stata V.16 software. Only studies reporting a valid strategy to control for reverse causality will be included.Discussion This review will provide evidence to support the importance of adherence on rate of smoking cessation and level of adherence to NRT. The findings will be used to inform smoking cessation interventions, researchers and policymakers.Ethics and dissemination As a systematic literature review, this protocol does not require ethics approval. Research outcomes will be presented at relevant conferences and findings will be published in a relevant peer-reviewed journal.PROSPERO registration number CRD42020176749. |
| format | Article |
| id | doaj-art-796827a02e31474ba455d6bec889013f |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2020-09-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-796827a02e31474ba455d6bec889013f2025-01-08T20:30:09ZengBMJ Publishing GroupBMJ Open2044-60552020-09-0110910.1136/bmjopen-2020-039775Evaluating level of adherence to nicotine replacement therapy and its impact on smoking cessation: a protocol for systematic review and meta-analysisMichelle Bovill0Gillian Sandra Gould1Amanual Getnet Mersha2Parivash Eftekhari3Daniel Nigusse Tollosa4Hunter Medical Research Institute, Lot 1, Kookaburra Circuit, New Lambton Heights, Newcastle 2305, NSW, AustraliaSchool of Medicine and Public Health, The University of Newcastle, Callaghan, New South Wales, Australia1 School of Medicine and Public Health, The University of Newcastle, Newcastle, New South Wales, AustraliaSchool of Medicine and Public Health, The University of Newcastle, University Drive, Callaghan, Newcastle 2308, New South Wales, AustraliaSchool of Medicine and Public Health, The University of Newcastle, University Drive, Callaghan, Newcastle 2308, New South Wales, AustraliaIntroduction Nicotine replacement therapy (NRT) has proven effective for smoking cessation in clinical trials, however it was found less effective in population-based studies, potentially due to inconsistent or incorrect use of NRT. The aim of this paper is to describe a systematic review protocol to evaluate level of adherence to NRT; the discrepancy of adherence to NRT in clinical and population-based studies and degree of association between level of adherence and success of smoking cessation.Methods and analysis Literature search will use five databases (Medline, Scopus, Embase, CINAHL and PsycINFO). Studies will be appraised for methodological quality using National Institutes of Health Quality Assessment Tool. To reduce heterogeneity, we will analyse clinical trials and population-based studies separately; pooled analyses will be done among studies that used similar measurements. Heterogeneity of studies will be assessed by Higgins’ I2 statistical test. When studies are adequately homogeneous, results will be pooled using random-effects model with proportion and ORs with 95% CIs and p values for each outcome. We will explain sources of heterogeneity by subgroup analysis or sensitivity analysis. Funnel plots and Egger’s regression asymmetry test with p<0.05 will be used as a cut-off point to affirm presence of statistically significant publication bias. Statistical analyses will be carried out using Stata V.16 software. Only studies reporting a valid strategy to control for reverse causality will be included.Discussion This review will provide evidence to support the importance of adherence on rate of smoking cessation and level of adherence to NRT. The findings will be used to inform smoking cessation interventions, researchers and policymakers.Ethics and dissemination As a systematic literature review, this protocol does not require ethics approval. Research outcomes will be presented at relevant conferences and findings will be published in a relevant peer-reviewed journal.PROSPERO registration number CRD42020176749.https://bmjopen.bmj.com/content/10/9/e039775.full |
| spellingShingle | Michelle Bovill Gillian Sandra Gould Amanual Getnet Mersha Parivash Eftekhari Daniel Nigusse Tollosa Evaluating level of adherence to nicotine replacement therapy and its impact on smoking cessation: a protocol for systematic review and meta-analysis BMJ Open |
| title | Evaluating level of adherence to nicotine replacement therapy and its impact on smoking cessation: a protocol for systematic review and meta-analysis |
| title_full | Evaluating level of adherence to nicotine replacement therapy and its impact on smoking cessation: a protocol for systematic review and meta-analysis |
| title_fullStr | Evaluating level of adherence to nicotine replacement therapy and its impact on smoking cessation: a protocol for systematic review and meta-analysis |
| title_full_unstemmed | Evaluating level of adherence to nicotine replacement therapy and its impact on smoking cessation: a protocol for systematic review and meta-analysis |
| title_short | Evaluating level of adherence to nicotine replacement therapy and its impact on smoking cessation: a protocol for systematic review and meta-analysis |
| title_sort | evaluating level of adherence to nicotine replacement therapy and its impact on smoking cessation a protocol for systematic review and meta analysis |
| url | https://bmjopen.bmj.com/content/10/9/e039775.full |
| work_keys_str_mv | AT michellebovill evaluatinglevelofadherencetonicotinereplacementtherapyanditsimpactonsmokingcessationaprotocolforsystematicreviewandmetaanalysis AT gilliansandragould evaluatinglevelofadherencetonicotinereplacementtherapyanditsimpactonsmokingcessationaprotocolforsystematicreviewandmetaanalysis AT amanualgetnetmersha evaluatinglevelofadherencetonicotinereplacementtherapyanditsimpactonsmokingcessationaprotocolforsystematicreviewandmetaanalysis AT parivasheftekhari evaluatinglevelofadherencetonicotinereplacementtherapyanditsimpactonsmokingcessationaprotocolforsystematicreviewandmetaanalysis AT danielnigussetollosa evaluatinglevelofadherencetonicotinereplacementtherapyanditsimpactonsmokingcessationaprotocolforsystematicreviewandmetaanalysis |