<i>Mucuna pruriens,</i> a Possible Treatment for Depressive Disorders
Depression is a mental disorder that depicts a wide variety of symptoms, including mood and cognitive alterations, as well as recurrent thoughts of death or suicide. It could become the second leading cause of premature death or disability worldwide. Treatments with conventional antidepressants have...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-11-01
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| Series: | Neurology International |
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| Online Access: | https://www.mdpi.com/2035-8377/16/6/112 |
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| author | Alfonso Mata-Bermudez Araceli Diaz-Ruiz Luis Ricardo Silva-García Eduardo Manuel Gines-Francisco Roxana Noriega-Navarro Camilo Rios Héctor Alonso Romero-Sánchez Diego Arroyo Abraham Landa Luz Navarro |
| author_facet | Alfonso Mata-Bermudez Araceli Diaz-Ruiz Luis Ricardo Silva-García Eduardo Manuel Gines-Francisco Roxana Noriega-Navarro Camilo Rios Héctor Alonso Romero-Sánchez Diego Arroyo Abraham Landa Luz Navarro |
| author_sort | Alfonso Mata-Bermudez |
| collection | DOAJ |
| description | Depression is a mental disorder that depicts a wide variety of symptoms, including mood and cognitive alterations, as well as recurrent thoughts of death or suicide. It could become the second leading cause of premature death or disability worldwide. Treatments with conventional antidepressants have several limitations in terms of effectiveness, side effects, and high costs. Therefore, medicinal plants such as <i>Mucuna pruriens</i> are potent candidates for treating depressive disorders. This review shows a compendium of evidence supporting the antidepressant effect of the <i>Mucuna pruriens</i> plant in diverse animal models. This includes the mechanisms of action underlying the antidepressant activity of the treatment concerning dopamine, serotonin, norepinephrine, reactive oxygen species, nitric oxide, cortisol, and inflammation. Clinical trials are needed to study the efficacy and safety of <i>Mucuna pruriens</i> for depression. |
| format | Article |
| id | doaj-art-795cd63a687d40e6ada34f0a4d75cd99 |
| institution | Kabale University |
| issn | 2035-8377 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Neurology International |
| spelling | doaj-art-795cd63a687d40e6ada34f0a4d75cd992024-12-27T14:43:50ZengMDPI AGNeurology International2035-83772024-11-011661509152710.3390/neurolint16060112<i>Mucuna pruriens,</i> a Possible Treatment for Depressive DisordersAlfonso Mata-Bermudez0Araceli Diaz-Ruiz1Luis Ricardo Silva-García2Eduardo Manuel Gines-Francisco3Roxana Noriega-Navarro4Camilo Rios5Héctor Alonso Romero-Sánchez6Diego Arroyo7Abraham Landa8Luz Navarro9Departamento de Fisiología, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad de México 04510, MexicoDepartamento de Neuroquímica, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suarez, Ciudad de México 14269, MexicoDepartamento de Atención a la Salud, Universidad Autónoma Metropolitana Unidad Xochimilco, Ciudad de México 04960, MexicoDepartamento de Atención a la Salud, Universidad Autónoma Metropolitana Unidad Xochimilco, Ciudad de México 04960, MexicoDepartamento de Fisiología, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad de México 04510, MexicoLaboratorio de Neurofarmacología Molecular, Departamento de Sistemas Biológicos, Universidad Autónoma Metropolitana Unidad Xochimilco, Ciudad de México 04960, MexicoDepartamento de Atención a la Salud, Universidad Autónoma Metropolitana Unidad Xochimilco, Ciudad de México 04960, MexicoDepartamento de Fisiología, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad de México 04510, MexicoDepartamento de Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad de México 04510, MexicoDepartamento de Fisiología, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad de México 04510, MexicoDepression is a mental disorder that depicts a wide variety of symptoms, including mood and cognitive alterations, as well as recurrent thoughts of death or suicide. It could become the second leading cause of premature death or disability worldwide. Treatments with conventional antidepressants have several limitations in terms of effectiveness, side effects, and high costs. Therefore, medicinal plants such as <i>Mucuna pruriens</i> are potent candidates for treating depressive disorders. This review shows a compendium of evidence supporting the antidepressant effect of the <i>Mucuna pruriens</i> plant in diverse animal models. This includes the mechanisms of action underlying the antidepressant activity of the treatment concerning dopamine, serotonin, norepinephrine, reactive oxygen species, nitric oxide, cortisol, and inflammation. Clinical trials are needed to study the efficacy and safety of <i>Mucuna pruriens</i> for depression.https://www.mdpi.com/2035-8377/16/6/112<i>Mucuna pruriens</i>depressioncatecholaminesoxidative stressnitric oxidecortisol |
| spellingShingle | Alfonso Mata-Bermudez Araceli Diaz-Ruiz Luis Ricardo Silva-García Eduardo Manuel Gines-Francisco Roxana Noriega-Navarro Camilo Rios Héctor Alonso Romero-Sánchez Diego Arroyo Abraham Landa Luz Navarro <i>Mucuna pruriens,</i> a Possible Treatment for Depressive Disorders Neurology International <i>Mucuna pruriens</i> depression catecholamines oxidative stress nitric oxide cortisol |
| title | <i>Mucuna pruriens,</i> a Possible Treatment for Depressive Disorders |
| title_full | <i>Mucuna pruriens,</i> a Possible Treatment for Depressive Disorders |
| title_fullStr | <i>Mucuna pruriens,</i> a Possible Treatment for Depressive Disorders |
| title_full_unstemmed | <i>Mucuna pruriens,</i> a Possible Treatment for Depressive Disorders |
| title_short | <i>Mucuna pruriens,</i> a Possible Treatment for Depressive Disorders |
| title_sort | i mucuna pruriens i a possible treatment for depressive disorders |
| topic | <i>Mucuna pruriens</i> depression catecholamines oxidative stress nitric oxide cortisol |
| url | https://www.mdpi.com/2035-8377/16/6/112 |
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