Simultaneous online monitoring of viscosity and oxygen transfer rate in shake flask cultures

Simultaneous online monitoring of viscosity and oxygen transfer rate in shake flask cultures

Abstract Shake flasks are among the most relevant culture vessels for early-stage process development of viscous microbial cultures. While online process monitoring systems are available for temperature, pH, biomass concentration, dissolved oxygen tension and respiration activity, online measuring t...

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Bibliographic Details
Main Authors: René Hanke, Michaela Sieben, Maurice Finger, Kilian Schnoor, Simon Jeßberger, Julia Weyand, Lluìs Coloma de la Fuente, Marcel Mann, Amizon Azizan, Udo Kosfeld, Jochen Büchs
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Journal of Biological Engineering
Subjects:
Bioprocess
Optical measurement
Paenibacillus polymyxa
Process analytical technology (PAT)
Respiratory activity monitoring system (RAMOS)
Rheology
Online Access:https://doi.org/10.1186/s13036-025-00552-6
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https://doi.org/10.1186/s13036-025-00552-6

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