Acute effect of a Mediterranean-style dietary pattern (MDP) on mood, anxiety and cognition in UK adults with mild to moderate anxiety and depression: the MediMood randomised controlled trial protocol
Introduction Psychological disorders including depression and anxiety are significant public health concerns. A Mediterranean-style dietary pattern (MDP) has been associated with improved mental well-being in observational studies. Evidence of the acute (defined as postprandial to 1 week) effects of...
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BMJ Publishing Group
2024-12-01
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| author | Emma Stevenson Amy Jennings Anne Marie Minihane Rachel Gillings Alpar Lazar M Hornberger Saber Sami Latife Esgunoglu Marrium Liaquat Adrian Leddy Jon Brooks William Penny |
| author_facet | Emma Stevenson Amy Jennings Anne Marie Minihane Rachel Gillings Alpar Lazar M Hornberger Saber Sami Latife Esgunoglu Marrium Liaquat Adrian Leddy Jon Brooks William Penny |
| author_sort | Emma Stevenson |
| collection | DOAJ |
| description | Introduction Psychological disorders including depression and anxiety are significant public health concerns. A Mediterranean-style dietary pattern (MDP) has been associated with improved mental well-being in observational studies. Evidence of the acute (defined as postprandial to 1 week) effects of an MDP on brain function, mood, cognition and important modulators, including sleep and the gut microbiota is limited. The current intervention aims to examine whether an MDP, compared with a Western diet (WD), improves mood, cognition and anxiety symptoms, postprandially, at 24-hour and after 5 days in adults with mild to moderate anxiety and depression.Methods and analysis Twenty-five UK adults (aged 18 or over) with mild to moderate anxiety and/or depression and low adherence to an MDP were recruited to a cross-over randomised controlled trial. Each participant undergoes a 5 day MDP and a 5 day WD in a randomised order with all meals provided. The co-primary outcomes are mood and anxiety, with secondary outcomes including cognitive function, brain perfusion (as assessed by MRI), sleep quality, blood pressure, plasma glucose, insulin, lipids, C-reactive protein, cortisol, brain-derived neurotrophic factor, gut microbiota speciation and microbial metabolites including short chain fatty acids. A linear mixed model and/or paired analysis will be used to compare the effects of treatments over time.Ethics and dissemination The study has received a favourable ethics opinion from the National Health Service London Queen Square Research Ethics Committee (22/LO/0796). The results will be disseminated through scientific journals and conferences.Trial registration number NCT05927376. |
| format | Article |
| id | doaj-art-78f475b76a534a4fb77f49cf9acb46e2 |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMJ Publishing Group |
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| series | BMJ Open |
| spelling | doaj-art-78f475b76a534a4fb77f49cf9acb46e22025-01-14T08:10:15ZengBMJ Publishing GroupBMJ Open2044-60552024-12-01141210.1136/bmjopen-2023-082935Acute effect of a Mediterranean-style dietary pattern (MDP) on mood, anxiety and cognition in UK adults with mild to moderate anxiety and depression: the MediMood randomised controlled trial protocolEmma Stevenson0Amy Jennings1Anne Marie Minihane2Rachel Gillings3Alpar Lazar4M Hornberger5Saber Sami6Latife Esgunoglu7Marrium Liaquat8Adrian Leddy9Jon Brooks10William Penny114 Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK1 Norwich Medical School, University of East Anglia, Norwich, UK1 Norwich Medical School, University of East Anglia, Norwich, UK1 Norwich Medical School, University of East Anglia, Norwich, UK2 School of Health Sciences, University of East Anglia, Norwich, UK1 Norwich Medical School, University of East Anglia, Norwich, UK1 Norwich Medical School, University of East Anglia, Norwich, UK1 Norwich Medical School, University of East Anglia, Norwich, UK1 Norwich Medical School, University of East Anglia, Norwich, UK1 Norwich Medical School, University of East Anglia, Norwich, UK3 School of Psychology, University of East Anglia, Norwich, UK3 School of Psychology, University of East Anglia, Norwich, UKIntroduction Psychological disorders including depression and anxiety are significant public health concerns. A Mediterranean-style dietary pattern (MDP) has been associated with improved mental well-being in observational studies. Evidence of the acute (defined as postprandial to 1 week) effects of an MDP on brain function, mood, cognition and important modulators, including sleep and the gut microbiota is limited. The current intervention aims to examine whether an MDP, compared with a Western diet (WD), improves mood, cognition and anxiety symptoms, postprandially, at 24-hour and after 5 days in adults with mild to moderate anxiety and depression.Methods and analysis Twenty-five UK adults (aged 18 or over) with mild to moderate anxiety and/or depression and low adherence to an MDP were recruited to a cross-over randomised controlled trial. Each participant undergoes a 5 day MDP and a 5 day WD in a randomised order with all meals provided. The co-primary outcomes are mood and anxiety, with secondary outcomes including cognitive function, brain perfusion (as assessed by MRI), sleep quality, blood pressure, plasma glucose, insulin, lipids, C-reactive protein, cortisol, brain-derived neurotrophic factor, gut microbiota speciation and microbial metabolites including short chain fatty acids. A linear mixed model and/or paired analysis will be used to compare the effects of treatments over time.Ethics and dissemination The study has received a favourable ethics opinion from the National Health Service London Queen Square Research Ethics Committee (22/LO/0796). The results will be disseminated through scientific journals and conferences.Trial registration number NCT05927376.https://bmjopen.bmj.com/content/14/12/e082935.full |
| spellingShingle | Emma Stevenson Amy Jennings Anne Marie Minihane Rachel Gillings Alpar Lazar M Hornberger Saber Sami Latife Esgunoglu Marrium Liaquat Adrian Leddy Jon Brooks William Penny Acute effect of a Mediterranean-style dietary pattern (MDP) on mood, anxiety and cognition in UK adults with mild to moderate anxiety and depression: the MediMood randomised controlled trial protocol BMJ Open |
| title | Acute effect of a Mediterranean-style dietary pattern (MDP) on mood, anxiety and cognition in UK adults with mild to moderate anxiety and depression: the MediMood randomised controlled trial protocol |
| title_full | Acute effect of a Mediterranean-style dietary pattern (MDP) on mood, anxiety and cognition in UK adults with mild to moderate anxiety and depression: the MediMood randomised controlled trial protocol |
| title_fullStr | Acute effect of a Mediterranean-style dietary pattern (MDP) on mood, anxiety and cognition in UK adults with mild to moderate anxiety and depression: the MediMood randomised controlled trial protocol |
| title_full_unstemmed | Acute effect of a Mediterranean-style dietary pattern (MDP) on mood, anxiety and cognition in UK adults with mild to moderate anxiety and depression: the MediMood randomised controlled trial protocol |
| title_short | Acute effect of a Mediterranean-style dietary pattern (MDP) on mood, anxiety and cognition in UK adults with mild to moderate anxiety and depression: the MediMood randomised controlled trial protocol |
| title_sort | acute effect of a mediterranean style dietary pattern mdp on mood anxiety and cognition in uk adults with mild to moderate anxiety and depression the medimood randomised controlled trial protocol |
| url | https://bmjopen.bmj.com/content/14/12/e082935.full |
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