Functions of double‐negative B cells in autoimmune diseases, infections, and cancers
Abstract Most mature B cells can be divided into four subtypes based on the expression of the surface markers IgD and CD27: IgD+CD27− naïve B cells, IgD+CD27+ unswitched memory B cells, IgD−CD27+ switched memory B cells, and IgD−CD27− double‐negative (DN) B cells. Despite their small population size...
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| Format: | Article |
| Language: | English |
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Springer Nature
2023-06-01
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| Series: | EMBO Molecular Medicine |
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| Online Access: | https://doi.org/10.15252/emmm.202217341 |
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| author | Michael King Yung Chung Lanqi Gong Dora Lai‐Wan Kwong Victor Ho‐Fun Lee Ann Wing‐Mui Lee Xin‐Yuan Guan Ngar‐Woon Kam Wei Dai |
| author_facet | Michael King Yung Chung Lanqi Gong Dora Lai‐Wan Kwong Victor Ho‐Fun Lee Ann Wing‐Mui Lee Xin‐Yuan Guan Ngar‐Woon Kam Wei Dai |
| author_sort | Michael King Yung Chung |
| collection | DOAJ |
| description | Abstract Most mature B cells can be divided into four subtypes based on the expression of the surface markers IgD and CD27: IgD+CD27− naïve B cells, IgD+CD27+ unswitched memory B cells, IgD−CD27+ switched memory B cells, and IgD−CD27− double‐negative (DN) B cells. Despite their small population size in normal peripheral blood, DN B cells play integral roles in various diseases. For example, they generate autoimmunity in autoimmune conditions, while these cells may generate both autoimmune and antipathogenic responses in COVID‐19, or act in a purely antipathogenic capacity in malaria. Recently, DN B cells have been identified in nasopharyngeal carcinoma and non‐small‐cell lung cancers, where they may play an immunosuppressive role. The distinct functions that DN B cells play in different diseases suggest that they are a heterogeneous B‐cell population. Therefore, further study of the mechanisms underlying the involvement of DN B cells in these diseases is essential for understanding their pathogenesis and the development of therapeutic strategies. Further research is thus warranted to characterize the DN B‐cell population in detail. |
| format | Article |
| id | doaj-art-78bcf946e0624a75acf06b34b53ade09 |
| institution | Kabale University |
| issn | 1757-4676 1757-4684 |
| language | English |
| publishDate | 2023-06-01 |
| publisher | Springer Nature |
| record_format | Article |
| series | EMBO Molecular Medicine |
| spelling | doaj-art-78bcf946e0624a75acf06b34b53ade092024-11-10T12:37:50ZengSpringer NatureEMBO Molecular Medicine1757-46761757-46842023-06-0115911410.15252/emmm.202217341Functions of double‐negative B cells in autoimmune diseases, infections, and cancersMichael King Yung Chung0Lanqi Gong1Dora Lai‐Wan Kwong2Victor Ho‐Fun Lee3Ann Wing‐Mui Lee4Xin‐Yuan Guan5Ngar‐Woon Kam6Wei Dai7Department of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong KongDepartment of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong KongDepartment of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong KongDepartment of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong KongDepartment of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong KongDepartment of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong KongDepartment of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong KongDepartment of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong KongAbstract Most mature B cells can be divided into four subtypes based on the expression of the surface markers IgD and CD27: IgD+CD27− naïve B cells, IgD+CD27+ unswitched memory B cells, IgD−CD27+ switched memory B cells, and IgD−CD27− double‐negative (DN) B cells. Despite their small population size in normal peripheral blood, DN B cells play integral roles in various diseases. For example, they generate autoimmunity in autoimmune conditions, while these cells may generate both autoimmune and antipathogenic responses in COVID‐19, or act in a purely antipathogenic capacity in malaria. Recently, DN B cells have been identified in nasopharyngeal carcinoma and non‐small‐cell lung cancers, where they may play an immunosuppressive role. The distinct functions that DN B cells play in different diseases suggest that they are a heterogeneous B‐cell population. Therefore, further study of the mechanisms underlying the involvement of DN B cells in these diseases is essential for understanding their pathogenesis and the development of therapeutic strategies. Further research is thus warranted to characterize the DN B‐cell population in detail.https://doi.org/10.15252/emmm.202217341autoimmune diseasecancer immunosuppressionCOVID‐19double‐negative B cellstumor microenvironment |
| spellingShingle | Michael King Yung Chung Lanqi Gong Dora Lai‐Wan Kwong Victor Ho‐Fun Lee Ann Wing‐Mui Lee Xin‐Yuan Guan Ngar‐Woon Kam Wei Dai Functions of double‐negative B cells in autoimmune diseases, infections, and cancers EMBO Molecular Medicine autoimmune disease cancer immunosuppression COVID‐19 double‐negative B cells tumor microenvironment |
| title | Functions of double‐negative B cells in autoimmune diseases, infections, and cancers |
| title_full | Functions of double‐negative B cells in autoimmune diseases, infections, and cancers |
| title_fullStr | Functions of double‐negative B cells in autoimmune diseases, infections, and cancers |
| title_full_unstemmed | Functions of double‐negative B cells in autoimmune diseases, infections, and cancers |
| title_short | Functions of double‐negative B cells in autoimmune diseases, infections, and cancers |
| title_sort | functions of double negative b cells in autoimmune diseases infections and cancers |
| topic | autoimmune disease cancer immunosuppression COVID‐19 double‐negative B cells tumor microenvironment |
| url | https://doi.org/10.15252/emmm.202217341 |
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