In silico investigation of ketamine and methylphenidate drug-drug conjugate for MDD and ADHD treatment using MD simulations and MMGBSA

In silico investigation of ketamine and methylphenidate drug-drug conjugate for MDD and ADHD treatment using MD simulations and MMGBSA

Abstract Major depressive disorder (MDD) and Attention-deficit hyperactivity disorder (ADHD) are pervasive psychiatric disorders characterized by impaired memory, sustained attention/motivation, and depression. FDA-approved Ketamine is an antidepressant drug but it affects cognitive abilities. Methy...

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Bibliographic Details
Main Authors: Beenish Asrar, Nouman Ali, Imran Ali, Muhammad Naveed
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Attention-deficit/hyperactivity disorder
Depression
Ketamine
Methylphenidate
Molecular docking
Tryptophane hydroxylase 2
Online Access:https://doi.org/10.1038/s41598-024-82302-0
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