Brg1 and RUNX1 synergy in regulating TRPM4 channel in mouse cardiomyocytes

Brg1 and RUNX1 synergy in regulating TRPM4 channel in mouse cardiomyocytes

BackgroundTransient Receptor Potential Melastatin 4 (TRPM4), a non-selective cation channel, plays a critical role in cardiac conduction abnormalities. Brg1, an ATP-dependent chromatin remodeler, is essential for regulating gene expression in both heart development and disease. Our previous studies...

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Main Authors: Tao Ban, Xianhui Dong, Ziyue Ma, Jing Jin, Jing Li, Yunfeng Cui, Yuyang Fu, Yongzhen Wang, Yadong Xue, Tingting Tong, Kai Zhang, Yuxuan Han, Meimei Shen, Yu Zhao, Ling Zhao, Lingzhao Xiong, Hongzhao Lv, Yang Liu, Rong Huo
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Pharmacology
Subjects:
TRPM4
BRG1
Runx1
hypoxia
cardiomyocyte
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1494205/full
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