Activation of glial cells induces proinflammatory properties in brain capillary endothelial cells in vitro

Activation of glial cells induces proinflammatory properties in brain capillary endothelial cells in vitro

Abstract Neurodegenerative diseases are often accompanied by neuroinflammation and impairment of the blood-brain barrier (BBB) mediated by activated glial cells through their release of proinflammatory molecules. To study the effects of glial cells on mouse brain endothelial cells (mBECs), we develo...

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Main Authors: Annette Burkhart, Steinunn Sara Helgudóttir, Yahye A. Mahamed, Mikkel B. Fruergaard, Julie N. Holm-Jacobsen, Hulda Haraldsdóttir, Sara E. Dahl, Freja Pretzmann, Lisa Greve Routhe, Kate Lambertsen, Torben Moos, Maj Schneider Thomsen
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Scientific Reports
Subjects:
Blood-brain barrier
Neuroinflammation
In-vitro BBB model
Glial cells
Lipopolysaccharide
Online Access:https://doi.org/10.1038/s41598-024-78204-w
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https://doi.org/10.1038/s41598-024-78204-w

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