PIGK defects induce apoptosis in Purkinje cells and acceleration of neuroectodermal differentiation

PIGK defects induce apoptosis in Purkinje cells and acceleration of neuroectodermal differentiation

Abstract Biallelic mutations in PIGK cause GPI biosynthesis defect 22 (GPIBD22), characterized with developmental delay, hypotonia, and cerebellar atrophy. The understanding of the underlying causes is limited due to the lack of suitable disease models. To address this gap, we generated a mouse mode...

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Main Authors: Siyi Chen, Jiali You, Xiaowei Zhou, Yan Li, Fang Liu, Yanling Teng, Hua Teng, Yunlong Li, Desheng Liang, Zhuo Li, Lingqian Wu
Format: Article
Language:English
Published: Nature Publishing Group 2024-11-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-024-07201-8
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https://doi.org/10.1038/s41419-024-07201-8

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