Advances in Selenium and Related Compounds Inhibiting Multi-Organ Fibrosis
Xixi Xiao,1 Guoquan Huang,2,3 Xinqiao Yu,2 Yong Tan2,3 1The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Hubei Minzu University, Enshi, 445000, People’s Republic of China; 2Hubei Selenium and Human Health Institute, The Central Hospital of Enshi Tujia and Miao Autonomous Prefectur...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2025-01-01
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| Series: | Drug Design, Development and Therapy |
| Subjects: | |
| Online Access: | https://www.dovepress.com/advances-in-selenium-and-related-compounds-inhibiting-multi-organ-fibr-peer-reviewed-fulltext-article-DDDT |
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| Summary: | Xixi Xiao,1 Guoquan Huang,2,3 Xinqiao Yu,2 Yong Tan2,3 1The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Hubei Minzu University, Enshi, 445000, People’s Republic of China; 2Hubei Selenium and Human Health Institute, The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Enshi, 445000, People’s Republic of China; 3Hubei Provincial Key Laboratory of Selenium Resources and Bioapplications, Enshi, 445000, People’s Republic of ChinaCorrespondence: Xinqiao Yu; Yong Tan, Email 1361095717@qq.com; tanyong951018@163.comAbstract: Selenium (Se), a critically essential trace element, plays a crucial role in diverse physiological processes within the human body, such as oxidative stress response, inflammation regulation, apoptosis, and lipid metabolism. Organ fibrosis, a pathological condition caused by various factors, has become a significant global health issue. Numerous studies have demonstrated the substantial impact of Se on fibrotic diseases. This review delves into the latest research advancements in Se and Se-related biological agents for alleviating fibrosis in the heart, liver, lungs, and kidneys, detailing their mechanisms of action within fibrotic pathways. Additionally, the article summa-rizes some of the anti-fibrotic drugs currently in clinical trials for the aforementioned organ fibroses.Keywords: selenium, fibrosis, organ, clinical |
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| ISSN: | 1177-8881 |