High systemic inflammation response index (SIRI) level as a prognostic factor for colorectal cancer patients after curative surgery: a single-center retrospective analysis
Abstract The Systemic Inflammation Response Index (SIRI), a marker used to assess systemic inflammation, is associated with lower patient survival rates in various cancer types. Factors contributing to the recurrence of colorectal cancer (CRC) have been examined previously using the preoperative SIR...
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Nature Portfolio
2025-01-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-024-84991-z |
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| author | Tamuro Hayama Hiroki Ochiai Tsuyoshi Ozawa Toshiya Miyata Kentaro Asako Yoshihisa Fukushima Kensuke Kaneko Keijiro Nozawa Shoichi Fujii Takeyuki Misawa Takeo Fukagawa |
| author_facet | Tamuro Hayama Hiroki Ochiai Tsuyoshi Ozawa Toshiya Miyata Kentaro Asako Yoshihisa Fukushima Kensuke Kaneko Keijiro Nozawa Shoichi Fujii Takeyuki Misawa Takeo Fukagawa |
| author_sort | Tamuro Hayama |
| collection | DOAJ |
| description | Abstract The Systemic Inflammation Response Index (SIRI), a marker used to assess systemic inflammation, is associated with lower patient survival rates in various cancer types. Factors contributing to the recurrence of colorectal cancer (CRC) have been examined previously using the preoperative SIRI. Herein, we investigated the association between the preoperative SIRI level and both the recurrence-free survival (RFS) and overall survival (OS) in patients diagnosed with CRC. We retrospectively analyzed the case of 406 patients who underwent curative surgery for Stage I-III CRC at a single institution during 2012- 2017. Based on their SIRI levels, we categorized the patients into a low-SIRI group (≤ 1700) and a high-SIRI group (> 1700). Multivariable analyses revealed that a high-SIRI level was an independent risk factor for 5-year RFS (p = 0.045) and OS (p = 0.048) in CRC patients. A Kaplan–Meier analysis demonstrated significantly poorer 5-year RFS and OS outcomes in the high-SIRI group compared to the low-SIRI group (p = 0.0001, p = 0.017 respectively). These findings suggest that the high-SIRI level is significantly associated with a poorer prognosis in patients diagnosed with CRC. |
| format | Article |
| id | doaj-art-76e4e9dd262741548fcc146ddc351909 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-76e4e9dd262741548fcc146ddc3519092025-01-12T12:20:07ZengNature PortfolioScientific Reports2045-23222025-01-011511910.1038/s41598-024-84991-zHigh systemic inflammation response index (SIRI) level as a prognostic factor for colorectal cancer patients after curative surgery: a single-center retrospective analysisTamuro Hayama0Hiroki Ochiai1Tsuyoshi Ozawa2Toshiya Miyata3Kentaro Asako4Yoshihisa Fukushima5Kensuke Kaneko6Keijiro Nozawa7Shoichi Fujii8Takeyuki Misawa9Takeo Fukagawa10Department of Surgery, Teikyo University School of MedicineDepartment of Surgery, Teikyo University School of MedicineDepartment of Surgical Oncology, Graduate School of Medicine, The University of TokyoDepartment of Surgery, Teikyo University School of MedicineDepartment of Surgery, Teikyo University School of MedicineDepartment of Surgery, Teikyo University School of MedicineDepartment of Surgery, Teikyo University School of MedicineDepartment of Surgery, Teikyo University School of MedicineDepartment of Surgery, Yokohama General HospitalDepartment of Surgery, Teikyo University School of MedicineDepartment of Surgery, Teikyo University School of MedicineAbstract The Systemic Inflammation Response Index (SIRI), a marker used to assess systemic inflammation, is associated with lower patient survival rates in various cancer types. Factors contributing to the recurrence of colorectal cancer (CRC) have been examined previously using the preoperative SIRI. Herein, we investigated the association between the preoperative SIRI level and both the recurrence-free survival (RFS) and overall survival (OS) in patients diagnosed with CRC. We retrospectively analyzed the case of 406 patients who underwent curative surgery for Stage I-III CRC at a single institution during 2012- 2017. Based on their SIRI levels, we categorized the patients into a low-SIRI group (≤ 1700) and a high-SIRI group (> 1700). Multivariable analyses revealed that a high-SIRI level was an independent risk factor for 5-year RFS (p = 0.045) and OS (p = 0.048) in CRC patients. A Kaplan–Meier analysis demonstrated significantly poorer 5-year RFS and OS outcomes in the high-SIRI group compared to the low-SIRI group (p = 0.0001, p = 0.017 respectively). These findings suggest that the high-SIRI level is significantly associated with a poorer prognosis in patients diagnosed with CRC.https://doi.org/10.1038/s41598-024-84991-zColorectal cancerSIRIPrognosisOSRFS |
| spellingShingle | Tamuro Hayama Hiroki Ochiai Tsuyoshi Ozawa Toshiya Miyata Kentaro Asako Yoshihisa Fukushima Kensuke Kaneko Keijiro Nozawa Shoichi Fujii Takeyuki Misawa Takeo Fukagawa High systemic inflammation response index (SIRI) level as a prognostic factor for colorectal cancer patients after curative surgery: a single-center retrospective analysis Scientific Reports Colorectal cancer SIRI Prognosis OS RFS |
| title | High systemic inflammation response index (SIRI) level as a prognostic factor for colorectal cancer patients after curative surgery: a single-center retrospective analysis |
| title_full | High systemic inflammation response index (SIRI) level as a prognostic factor for colorectal cancer patients after curative surgery: a single-center retrospective analysis |
| title_fullStr | High systemic inflammation response index (SIRI) level as a prognostic factor for colorectal cancer patients after curative surgery: a single-center retrospective analysis |
| title_full_unstemmed | High systemic inflammation response index (SIRI) level as a prognostic factor for colorectal cancer patients after curative surgery: a single-center retrospective analysis |
| title_short | High systemic inflammation response index (SIRI) level as a prognostic factor for colorectal cancer patients after curative surgery: a single-center retrospective analysis |
| title_sort | high systemic inflammation response index siri level as a prognostic factor for colorectal cancer patients after curative surgery a single center retrospective analysis |
| topic | Colorectal cancer SIRI Prognosis OS RFS |
| url | https://doi.org/10.1038/s41598-024-84991-z |
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