Wenyang Jiedu Tongluo formula ameliorates diabetic kidney disease by regulating JAML/SIRT1 signaling to improve lipid metabolism in db/db mice

Wenyang Jiedu Tongluo formula ameliorates diabetic kidney disease by regulating JAML/SIRT1 signaling to improve lipid metabolism in db/db mice

IntroductionDiabetic kidney disease (DKD), a major microvascular complication of diabetes mellitus, is closely associated with abnormal lipid metabolism, which contributes to secondary renal injury. The JAML/SIRT1 signaling pathway plays a critical role in regulating renal lipid metabolism during DK...

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Bibliographic Details
Main Authors: Yutong Liu, Tianying Chang, Zikun Wang, Hongkai Liu, Fan Li, Chengji Cui, Yingzi Cui, Shoulin Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Pharmacology
Subjects:
diabetic kidney disease
lipid metabolism
Wenyang Jiedu Tongluo formula
JAML/SIRT1 signaling pathway
traditional Chinese medicine
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1611585/full
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