A new nano approach to prevent tumor growth in the local treatment of glioblastoma: Temozolomide and rutin-loaded hybrid layered composite nanofiber

A new nano approach to prevent tumor growth in the local treatment of glioblastoma: Temozolomide and rutin-loaded hybrid layered composite nanofiber

Total resection of glioblastoma (GB) tumors is nearly impossible, and systemic administration of temozolomide (TMZ) is often inadequate. This study presents a hybrid layered composite nanofiber network (LHN) designed for localized treatment in GB tumor bed. The LHN, consisting of polyvinyl alcohol a...

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Main Authors: Melis Ercelik, Cagla Tekin, Melisa Gurbuz, Yagmur Tuncbilekli, Hazal Yılmaz Dogan, Busra Mutlu, Pınar Eser, Gulcin Tezcan, Fatma Nur Parın, Kenan Yildirim, Mehmet Sarihan, Gurler Akpinar, Murat Kasap, Ahmet Bekar, Hasan Kocaeli, Mevlut Ozgur Taskapilioglu, Secil Ak Aksoy, Rıfat Ozpar, Bahattin Hakyemez, Berrin Tunca
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Asian Journal of Pharmaceutical Sciences
Subjects:
Glioblastoma
Local treatment
Temozolomide
Rutin
Hybrid layered composite nanofiber network
Online Access:http://www.sciencedirect.com/science/article/pii/S1818087624000886
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