Chemical reprogramming ameliorates cellular hallmarks of aging and extends lifespan

Abstract The dedifferentiation of somatic cells into a pluripotent state by cellular reprogramming coincides with a reversal of age-associated molecular hallmarks. Although transcription factor induced cellular reprogramming has been shown to ameliorate these aging phenotypes in human cells and exte...

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Main Authors: Lucas Schoenfeldt, Patrick T Paine, Sara Picó, Nibrasul H Kamaludeen M, Grace B Phelps, Calida Mrabti, Gabriela Desdín-Micó, María del Carmen Maza, Kevin Perez, Alejandro Ocampo
Format: Article
Language:English
Published: Springer Nature 2025-06-01
Series:EMBO Molecular Medicine
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Online Access:https://doi.org/10.1038/s44321-025-00265-9
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