Association between alcohol consumption and risk of type 2 diabetes in Japan: a population-base longitudinal cohort study
Abstract Heavy alcohol consumption is a known risk factor for type 2 diabetes (T2D), However, the moderating effect of fasting plasma glucose (FPG) levels remains unclear. This study explores the relationship between alcohol intake and T2D risk across FPG strata in a Japanese cohort. Data from 15,45...
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Nature Portfolio
2025-01-01
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| Online Access: | https://doi.org/10.1038/s41598-024-84597-5 |
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| author | Yuan-Zhe Huang Fang Luo Xiong Ran Jian Yang Min Gu Shao-Quan Zhou |
| author_facet | Yuan-Zhe Huang Fang Luo Xiong Ran Jian Yang Min Gu Shao-Quan Zhou |
| author_sort | Yuan-Zhe Huang |
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| description | Abstract Heavy alcohol consumption is a known risk factor for type 2 diabetes (T2D), However, the moderating effect of fasting plasma glucose (FPG) levels remains unclear. This study explores the relationship between alcohol intake and T2D risk across FPG strata in a Japanese cohort. Data from 15,453 participants in the NAGALA cohort were analyzed over 5.4 years. Baseline assessments included alcohol consumption and FPG, categorizing individuals into elevated FPG (EFPG, 100–125 mg/dL) and normal FPG (NFPG, < 100 mg/dL). Cox proportional hazards regression assessed alcohol intake levels and T2D risk, stratified by FPG. Among EFPG individuals, heavy drinkers (Men > 280 g/week, Women > 140 g/week) had an 88% increased T2D risk (HR 1.88, 95% CI 1.24–2.84). Conversely, in NFPG, heavy alcohol intake did not significantly affect T2D risk (HR 1.10, 95% CI 0.48–2.53). Men with EFPG and heavy alcohol intake had an HR of 1.83 (95% CI 1.08–3.08), supported by propensity score matching (HR 1.94, 95% CI 1.13–3.34). No significant relationships were found in NFPG. Heavy alcohol consumption significantly raises T2D risk in Japanese men with EFPG but not in women or those with NFPG. Further studies are warranted for validation and gender-specific insights. |
| format | Article |
| id | doaj-art-7663f01e45894a6c99683abe28039292 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
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| spelling | doaj-art-7663f01e45894a6c99683abe280392922025-01-05T12:22:25ZengNature PortfolioScientific Reports2045-23222025-01-0115111010.1038/s41598-024-84597-5Association between alcohol consumption and risk of type 2 diabetes in Japan: a population-base longitudinal cohort studyYuan-Zhe Huang0Fang Luo1Xiong Ran2Jian Yang3Min Gu4Shao-Quan Zhou5Department of Radiology, Chongqing General Hospital, Chongqing UniversityDepartment of Gastroenterology, Chongqing Traditional Chinese Medicine Hospital, Chongqing Academy of Traditional Chinese MedicineDepartment of Radiology, Chongqing General Hospital, Chongqing UniversityDepartment of Radiology, Chongqing General Hospital, Chongqing UniversityDepartment of Radiology, Chongqing General Hospital, Chongqing UniversityDepartment of Radiology, Chongqing General Hospital, Chongqing UniversityAbstract Heavy alcohol consumption is a known risk factor for type 2 diabetes (T2D), However, the moderating effect of fasting plasma glucose (FPG) levels remains unclear. This study explores the relationship between alcohol intake and T2D risk across FPG strata in a Japanese cohort. Data from 15,453 participants in the NAGALA cohort were analyzed over 5.4 years. Baseline assessments included alcohol consumption and FPG, categorizing individuals into elevated FPG (EFPG, 100–125 mg/dL) and normal FPG (NFPG, < 100 mg/dL). Cox proportional hazards regression assessed alcohol intake levels and T2D risk, stratified by FPG. Among EFPG individuals, heavy drinkers (Men > 280 g/week, Women > 140 g/week) had an 88% increased T2D risk (HR 1.88, 95% CI 1.24–2.84). Conversely, in NFPG, heavy alcohol intake did not significantly affect T2D risk (HR 1.10, 95% CI 0.48–2.53). Men with EFPG and heavy alcohol intake had an HR of 1.83 (95% CI 1.08–3.08), supported by propensity score matching (HR 1.94, 95% CI 1.13–3.34). No significant relationships were found in NFPG. Heavy alcohol consumption significantly raises T2D risk in Japanese men with EFPG but not in women or those with NFPG. Further studies are warranted for validation and gender-specific insights.https://doi.org/10.1038/s41598-024-84597-5DiabetesAlcoholRisk factorsEpidemiology |
| spellingShingle | Yuan-Zhe Huang Fang Luo Xiong Ran Jian Yang Min Gu Shao-Quan Zhou Association between alcohol consumption and risk of type 2 diabetes in Japan: a population-base longitudinal cohort study Scientific Reports Diabetes Alcohol Risk factors Epidemiology |
| title | Association between alcohol consumption and risk of type 2 diabetes in Japan: a population-base longitudinal cohort study |
| title_full | Association between alcohol consumption and risk of type 2 diabetes in Japan: a population-base longitudinal cohort study |
| title_fullStr | Association between alcohol consumption and risk of type 2 diabetes in Japan: a population-base longitudinal cohort study |
| title_full_unstemmed | Association between alcohol consumption and risk of type 2 diabetes in Japan: a population-base longitudinal cohort study |
| title_short | Association between alcohol consumption and risk of type 2 diabetes in Japan: a population-base longitudinal cohort study |
| title_sort | association between alcohol consumption and risk of type 2 diabetes in japan a population base longitudinal cohort study |
| topic | Diabetes Alcohol Risk factors Epidemiology |
| url | https://doi.org/10.1038/s41598-024-84597-5 |
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