Metabolic Engineering of Glycofusion Bispecific Antibodies for α-Dystroglycanopathies

Metabolic Engineering of Glycofusion Bispecific Antibodies for α-Dystroglycanopathies

<b>Background:</b> α-dystroglycanopathies are congenital muscular dystrophies in which genetic mutations cause the decrease or absence of a unique and complex O-linked glycan called matriglycan. This hypoglycosylation of O-linked matriglycan on the α-dystroglycan (α-DG) protein subunit a...

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Main Authors: Xiaotian Zhong, Guoying Grace Yan, Apurva Chaturvedi, Xiuling Li, Yijie Gao, Mahasweta Girgenrath, Chris J. Corcoran, Liz Diblasio-Smith, Edward R. LaVallie, Teresse de Rham, Jing Zhou, Molica Abel, Logan Riegel, Sean K.H. Lim, Laird Bloom, Laura Lin, Aaron M. D’Antona
Format: Article
Language:English
Published: MDPI AG 2024-10-01
Series:Antibodies
Subjects:
metabolic engineering
glycofusion bispecific antibody
O-linked matriglycan
dystroglycan
mucin-like domain
dystroglycanopathies
Online Access:https://www.mdpi.com/2073-4468/13/4/83
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