Association of first-trimester exposure to Kampo medicines containing Prunus persica kernel with preterm birth and major congenital malformations: a Japanese database study

Association of first-trimester exposure to Kampo medicines containing Prunus persica kernel with preterm birth and major congenital malformations: a Japanese database study

IntroductionTraditional Japanese (Kampo) medicine containing Prunus persica kernel (KPK) is prescribed for treating menstrual- and pregnancy-related symptoms. However, no safety information is available regarding its use in pregnant women. In this study, we examined the associations of KPK prescript...

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Main Authors: Satoko Suzuki, Ryutaro Arita, Taku Obara, Tomofumi Ishikawa, Tadaharu Kunitoki, Takamasa Sakai, Aoi Noda, Genki Shinoda, Mami Ishikuro, Masatsugu Orui, Shinichi Kuriyama, Minoru Ohsawa, Ken Haneda, Nariyasu Mano, Akiko Kikuchi, Shin Takayama, Tadashi Ishii
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Pharmacology
Subjects:
database
pregnancy
malformation
preterm birth
Prunus persica kernel
Kampo medicine
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1562724/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1562724/full

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