Protocol for closed-loop optogenetic manipulation of cortical activity following hippocampal sharp-wave ripples in freely behaving rats

Summary: Temporally and spatially selective closed-loop perturbation of brain activity can be used to reveal the contribution of spontaneous neural events to behavior. Here, we present a protocol for optogenetic inhibition of the medial prefrontal cortex following hippocampal sharp-wave ripple event...

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Bibliographic Details
Main Authors: Hanna den Bakker, Jyh-Jang Sun, Marine Guyot, Fabian Kloosterman
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:STAR Protocols
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Online Access:http://www.sciencedirect.com/science/article/pii/S2666166725003041
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