Analytical methods for in-depth characterisation of cell culture bioreactors: A case study

Analytical methods for in-depth characterisation of cell culture bioreactors: A case study

Biopharmaceuticals and especially antibodies represent an expanding segment of pharmaceutical drug products. Production processes for this group of complex molecules use biological expression systems such as Chinese hamster ovary (CHO) cells, that are instrumental in their assembly, folding, and pos...

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Bibliographic Details
Main Authors: Janik D. Seidel, Clifford Young, Manuela Klingler-Hoffmann, Mark R. Condina, Alok Shah, Sri Ramarathinam, Woan Mei Kok, Craig Kyngdon, Peter Hoffmann
Format: Article
Language:English
Published: Elsevier 2025-11-01
Series:Journal of Chromatography Open
Subjects:
Host cell proteins
Amino acids
Mass spectrometry
High performance liquid chromatography
Bioreactors
Critical quality attributes
Online Access:http://www.sciencedirect.com/science/article/pii/S2772391725000465
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