IHH–GLI-1–HIF-2α signalling influences hypertrophic chondrocytes to exacerbate osteoarthritis progression

IHH–GLI-1–HIF-2α signalling influences hypertrophic chondrocytes to exacerbate osteoarthritis progression

Background: Chondrocyte hypertrophy is a potential target for osteoarthritis (OA) treatment, with Indian hedgehog (IHH), glioma-associated oncogene homolog (GLI), and hypoxia-inducible factor-2α (HIF-2α) being closely associated with chondrocyte hypertrophy during OA progression. Whereas IHH can mod...

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Bibliographic Details
Main Authors: Chengming Zhang, Ruipeng Zhao, Zhengquan Dong, Yang Liu, Mengrou Liu, Haoqian Li, Yukun Yin, Xianda Che, Gaige Wu, li Guo, Pengcui Li, Xiaochun Wei, Ziquan Yang
Format: Article
Language:English
Published: Elsevier 2024-11-01
Series:Journal of Orthopaedic Translation
Subjects:
Chondrocyte hypertrophy
GLI proteins
HIF-2α
Indian hedgehog
Osteoarthritis
Online Access:http://www.sciencedirect.com/science/article/pii/S2214031X24001244
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