Maximal inhibitory effect of MOV10 on LINE-1 retrotransposition requires both the MOV10/LINE-1 association and granule formation.

Maximal inhibitory effect of MOV10 on LINE-1 retrotransposition requires both the MOV10/LINE-1 association and granule formation.

LINE-1 is the only active autonomous mobile element in the human, and its mobilization is tightly restricted by the host to maintain genetic stability. We recently reported that human MOV10 recruits DCP2 to decap LINE-1 RNA by liquid-liquid phase separation (LLPS), resulting in the inhibition of LIN...

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Main Authors: Qian Liu, Yaqi Liu, Yang Mao, Dongrong Yi, Quanjie Li, Jiwei Ding, Saisai Guo, Yongxin Zhang, Jing Wang, Jianyuan Zhao, Ling Ma, Xiaozhong Peng, Shan Cen, Xiaoyu Li
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-05-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1011709
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https://doi.org/10.1371/journal.pgen.1011709

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