Glutamic Acid at Position 343 in PB2 Contributes to the Virulence of H1N1 Swine Influenza Virus in Mice

Glutamic Acid at Position 343 in PB2 Contributes to the Virulence of H1N1 Swine Influenza Virus in Mice

The H1N1 swine influenza viruses CQ91 and CQ445, isolated from pigs in China, exhibited distinct virulence in mice despite sharing similar genomic constellations. CQ91 demonstrated higher pathogenicity (MLD<sub>50</sub>: 5.4 log<sub>10</sub> EID<sub>50</sub>) and...

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Bibliographic Details
Main Authors: Yanwen Wang, Qiu Zhong, Fei Meng, Zhang Cheng, Yijie Zhang, Zuchen Song, Yali Zhang, Zijian Feng, Yujia Zhai, Yan Chen, Chuanling Qiao, Huanliang Yang
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Viruses
Subjects:
influenza virus
H1N1 subtype
PB2
molecular basis
pathogenicity
Online Access:https://www.mdpi.com/1999-4915/17/7/1018
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