Targeting TGFβR2‐mutant tumors exposes vulnerabilities to stromal TGFβ blockade in pancreatic cancer

Targeting TGFβR2‐mutant tumors exposes vulnerabilities to stromal TGFβ blockade in pancreatic cancer

Abstract TGFβ is important during pancreatic ductal adenocarcinoma (PDA) progression. Canonical TGFβ signaling suppresses epithelial pancreatic cancer cell proliferation; as a result, inhibiting TGFβ has not been successful in PDA. In contrast, we demonstrate that inhibition of stromal TGFβR2 reduce...

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Bibliographic Details
Main Authors: Huocong Huang, Yuqing Zhang, Valerie Gallegos, Noah Sorrelle, Mohamed Medhat Zaid, Jason Toombs, Wenting Du, Steven Wright, Moriah Hagopian, Zhaoning Wang, Abdel Nasser Hosein, Adwait Amod Sathe, Chao Xing, Eugene J Koay, Kyla E Driscoll, Rolf A Brekken
Format: Article
Language:English
Published: Springer Nature 2019-10-01
Series:EMBO Molecular Medicine
Subjects:
cancer‐associated fibroblast
IL‐6
pancreatic cancer
TGFβ
tumor immunology
Online Access:https://doi.org/10.15252/emmm.201910515
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https://doi.org/10.15252/emmm.201910515

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