Photodynamic-therapy and chemotherapy of TPBC-PEG nanoplatform encapsulated triptolide synergistically inhibit primary osteosarcoma growth and pulmonary metastasis by activating HIPPO signaling

Photodynamic-therapy and chemotherapy of TPBC-PEG nanoplatform encapsulated triptolide synergistically inhibit primary osteosarcoma growth and pulmonary metastasis by activating HIPPO signaling

Osteosarcoma is the most common bone malignancy in children and adolescents with a less than 30% overall survival rate for those with metastatic disease, particularly pulmonary metastases. Drug resistance hinders the effectiveness of current chemotherapies, making osteosarcoma a leading cause of mor...

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Bibliographic Details
Main Authors: Junli Chang, Wenyi Wang, Fulai Zhao, Xingyuan Sun, Suxia Guo, Chujie Zhou, Peng Zhao, Junjie Tong, Weian Zhang, Yanping Yang
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Materials & Design
Subjects:
Osteosarcoma
Pulmonary metastases
Triptolide
Photodynamic therapy
TP-TPBC-PEG
HIPPO signaling
Online Access:http://www.sciencedirect.com/science/article/pii/S0264127524008578
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