m6A-modified circZNF548 regulates exosomal miR-7108-3p to activate CD3+CD8+ T cells and suppress NSCLC growth by JMY

m6A-modified circZNF548 regulates exosomal miR-7108-3p to activate CD3+CD8+ T cells and suppress NSCLC growth by JMY

Abstract Background Communication between cancer cells and tumor microenvironment (TME) plays a complicated role in cancer malignancy. Circular RNAs (circRNAs), known for their stability and conservation, contribute to TME remodeling in various cancers. This study aims to investigate the role of N6-...

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Main Authors: Yu-Long Zhao, You-Jie Li, Chun-Xia Wu, Ning Xie, Xi-Yan Li, Dian-Chao Cao, Yang Guo, Yan Liang, Yan-Mei Li, Jiang-Nan Xue, Hong-Fang Sun, Qin Wang, Xiao-Hua Li, Ping-Yu Wang, Shu-Yang Xie
Format: Article
Language:English
Published: BMC 2025-08-01
Series:BMC Biology
Subjects:
circZNF548
Exosomal miR-7108-3p
Tumor microenvironment
JMY
CD8
Online Access:https://doi.org/10.1186/s12915-025-02355-z
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https://doi.org/10.1186/s12915-025-02355-z

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