Purine–Hydrazone Scaffolds as Potential Dual EGFR/HER2 Inhibitors

Purine–Hydrazone Scaffolds as Potential Dual EGFR/HER2 Inhibitors

<b>Background/Objectives:</b> The dual targeting of epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2) represents an effective approach for cancer treatment. The current study involved the design, synthesis, and biological evaluation of a new seri...

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Bibliographic Details
Main Authors: Fatemah S. Albalawi, Mashooq A. Bhat, Ahmed H. Bakheit, A. F. M. Motiur Rahman, Nawaf A. Alsaif, Alan M. Jones, Isolda Romero-Canelon
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Pharmaceuticals
Subjects:
cancer
EGFR
HER2
EGFR- and HER2-driven cancers
purine/hydrazone-containing compounds
lapatinib
Online Access:https://www.mdpi.com/1424-8247/18/7/1051
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https://www.mdpi.com/1424-8247/18/7/1051

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