Super broad and protective nanobodies against Sarbecoviruses including SARS-CoV-1 and the divergent SARS-CoV-2 subvariant KP.3.1.1.

Super broad and protective nanobodies against Sarbecoviruses including SARS-CoV-1 and the divergent SARS-CoV-2 subvariant KP.3.1.1.

The ongoing evolution and immune escape of SARS-CoV-2, alongside the potential threat of SARS-CoV-1 and other sarbecoviruses, underscore the urgent need for effective strategies against their infection and transmission. This study highlights the discovery of nanobodies from immunized alpacas, which...

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Main Authors: Haodi Dong, Runhong Zhou, Jing Chen, Jing Wei, Zimeng Wei, Ziqing Yang, Kun Zhu, Yufan Yang, Qianqian Yang, Na Liu, Yuting Chen, Yuhan Wu, Yan Liang, Yige Zeng, Qile Guo, Mingxi Li, Sisi Shan, Han Wang, Mengyue Niu, Isabella Yunfei Zeng, Xuanling Shi, Qi Zhang, Xinquan Wang, Zhiwei Chen, Linqi Zhang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2024-11-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1012625
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https://doi.org/10.1371/journal.ppat.1012625

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