High Schistosoma mansoni infection intensity is associated with distinct gut microbiota and low levels of systemic cytokines in children along the Albert-Nile, Northern Uganda

High Schistosoma mansoni infection intensity is associated with distinct gut microbiota and low levels of systemic cytokines in children along the Albert-Nile, Northern Uganda

Abstract Background Schistosomiasis disease that affects millions of people in sub–Saharan Africa, with a range of impacts on both host immune responses and the gut microbiome. The gut microbiota plays a fundamental role in the host’s nutrition, metabolism, protection against pathogens, and modulati...

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Main Authors: Julius Mulindwa, Ibra Lujumba, Caroline Musiime, Joyce Namulondo, Magambo Phillip Kimuda, Oscar Nyangiri, Gloria Cuu, Caroline Mwubaha, Stephen Tukwasibwe, Aloysious Ssemaganda, Isaac Ssewanyana, Barbara Nerima, Rhona Baingana, Harry Noyes, Annette MacLeod, Enock Matovu
Format: Article
Language:English
Published: BMC 2025-08-01
Series:BMC Microbiology
Subjects:
Schistosoma mansoni
Infection intensity
Gut microbiota
Cytokine profiles
Online Access:https://doi.org/10.1186/s12866-025-04252-5
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https://doi.org/10.1186/s12866-025-04252-5

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