Horizontal and vertical optic disc rotation. The Beijing Eye Study.
<h4>Purpose</h4>To measure the optic disc rotation around the vertical and horizontal disc axis and to evaluate associations with general and ocular parameters.<h4>Design</h4>Population-based study.<h4>Methods</h4>In the Beijing Eye Study, 3468 participants (mean...
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Public Library of Science (PLoS)
2017-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0175749&type=printable |
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| author | Yuan Yuan Fan Jost B Jonas Ya Xing Wang Chang Xi Chen Wen Bin Wei |
| author_facet | Yuan Yuan Fan Jost B Jonas Ya Xing Wang Chang Xi Chen Wen Bin Wei |
| author_sort | Yuan Yuan Fan |
| collection | DOAJ |
| description | <h4>Purpose</h4>To measure the optic disc rotation around the vertical and horizontal disc axis and to evaluate associations with general and ocular parameters.<h4>Design</h4>Population-based study.<h4>Methods</h4>In the Beijing Eye Study, 3468 participants (mean age:64.6±9.8 years; range:50-93 years) underwent an ophthalmological examination which included spectral-domain optical coherence tomography (OCT) with enhanced depth imaging. Using the OCT images, we determined the amount of the rotation of the optic disc (defined as Bruch´s membrane opening (BMO)) around the vertical axis and horizontal axis.<h4>Results</h4>Optic disc rotation measurements were available for 3037 (87.6%) individuals. In multivariate analysis, larger optic disc rotation around the vertical axis (range:-4.90° to 41.0°) was associated (regression coefficient r:0.27) with high axial myopia (axial length ≥26.5 mm) (P<0.001;standardized regression coefficient beta beta:0.09), longer disc-fovea distance (P = 0.001;beta:0.09) and wider parapapillary beta/gamma zone (P<0.001;beta0.12). Larger optic disc rotation around the horizontal axis (range:-7.10° to 26.4°) was associated (r:0.32) with high axial myopia (P = 0.001;beta:0.08), larger optic disc-fovea angle (P<0.001;beta:0.13), thinner superior nasal retinal nerve fiber layer (RNFL) thickness (P<0.001;beta:-0.19) and thicker inferior nasal RNFL thickness (P<0.001;beta:0.17).<h4>Conclusions</h4>Vertical optic disc rotation was associated with highly myopic axial elongation, increased disc-fovea distance and development or enlargement of parapapillary, Bruch´s membrane free, gamma zone, while macular Bruch´s membrane length is not affected. Horizontal optic disc rotation was associated with inferior dislocation of the fovea, in addition to a thinner superior nasal RNFL and thicker inferior nasal RNFL. The latter association may be taken into account in the interpretation of RNFL thickness profiles. |
| format | Article |
| id | doaj-art-740dc3265f3f4ebf8202093eca03d749 |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS ONE |
| spelling | doaj-art-740dc3265f3f4ebf8202093eca03d7492025-01-17T05:32:08ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01125e017574910.1371/journal.pone.0175749Horizontal and vertical optic disc rotation. The Beijing Eye Study.Yuan Yuan FanJost B JonasYa Xing WangChang Xi ChenWen Bin Wei<h4>Purpose</h4>To measure the optic disc rotation around the vertical and horizontal disc axis and to evaluate associations with general and ocular parameters.<h4>Design</h4>Population-based study.<h4>Methods</h4>In the Beijing Eye Study, 3468 participants (mean age:64.6±9.8 years; range:50-93 years) underwent an ophthalmological examination which included spectral-domain optical coherence tomography (OCT) with enhanced depth imaging. Using the OCT images, we determined the amount of the rotation of the optic disc (defined as Bruch´s membrane opening (BMO)) around the vertical axis and horizontal axis.<h4>Results</h4>Optic disc rotation measurements were available for 3037 (87.6%) individuals. In multivariate analysis, larger optic disc rotation around the vertical axis (range:-4.90° to 41.0°) was associated (regression coefficient r:0.27) with high axial myopia (axial length ≥26.5 mm) (P<0.001;standardized regression coefficient beta beta:0.09), longer disc-fovea distance (P = 0.001;beta:0.09) and wider parapapillary beta/gamma zone (P<0.001;beta0.12). Larger optic disc rotation around the horizontal axis (range:-7.10° to 26.4°) was associated (r:0.32) with high axial myopia (P = 0.001;beta:0.08), larger optic disc-fovea angle (P<0.001;beta:0.13), thinner superior nasal retinal nerve fiber layer (RNFL) thickness (P<0.001;beta:-0.19) and thicker inferior nasal RNFL thickness (P<0.001;beta:0.17).<h4>Conclusions</h4>Vertical optic disc rotation was associated with highly myopic axial elongation, increased disc-fovea distance and development or enlargement of parapapillary, Bruch´s membrane free, gamma zone, while macular Bruch´s membrane length is not affected. Horizontal optic disc rotation was associated with inferior dislocation of the fovea, in addition to a thinner superior nasal RNFL and thicker inferior nasal RNFL. The latter association may be taken into account in the interpretation of RNFL thickness profiles.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0175749&type=printable |
| spellingShingle | Yuan Yuan Fan Jost B Jonas Ya Xing Wang Chang Xi Chen Wen Bin Wei Horizontal and vertical optic disc rotation. The Beijing Eye Study. PLoS ONE |
| title | Horizontal and vertical optic disc rotation. The Beijing Eye Study. |
| title_full | Horizontal and vertical optic disc rotation. The Beijing Eye Study. |
| title_fullStr | Horizontal and vertical optic disc rotation. The Beijing Eye Study. |
| title_full_unstemmed | Horizontal and vertical optic disc rotation. The Beijing Eye Study. |
| title_short | Horizontal and vertical optic disc rotation. The Beijing Eye Study. |
| title_sort | horizontal and vertical optic disc rotation the beijing eye study |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0175749&type=printable |
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