Recent advances in the regulatory and non-coding RNA biology of osteogenic differentiation: biological functions and significance for bone healing
Injuries associated with contemporary life, such as automobile crashes and sports injuries, can lead to large numbers of traumatic neuromuscular injuries that are intimately associated with bone fractures. Regulatory and non-coding RNAs play essential roles in multiple cellular processes, including...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2024.1483843/full |
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| author | Samaris Aranguren Hisae Cole Lauren Jeannette Dargan Madison Sarlo Sumin Choi Isha Satapathy Jaira Ferreira de Vasconcellos |
| author_facet | Samaris Aranguren Hisae Cole Lauren Jeannette Dargan Madison Sarlo Sumin Choi Isha Satapathy Jaira Ferreira de Vasconcellos |
| author_sort | Samaris Aranguren |
| collection | DOAJ |
| description | Injuries associated with contemporary life, such as automobile crashes and sports injuries, can lead to large numbers of traumatic neuromuscular injuries that are intimately associated with bone fractures. Regulatory and non-coding RNAs play essential roles in multiple cellular processes, including osteogenic differentiation and bone healing. In this review, we discuss the most recent advances in our understanding of the regulatory and non-coding RNA biology of osteogenic differentiation in stem, stromal and progenitor cells. We focused on circular RNAs, small nucleolar RNAs and PIWI-interacting RNAs and comprehensively summarized their biological functions as well as discussed their significance for bone healing and tissue regeneration. |
| format | Article |
| id | doaj-art-73ff0563f3564fde9087d2f22366de16 |
| institution | Kabale University |
| issn | 2296-634X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj-art-73ff0563f3564fde9087d2f22366de162025-01-06T06:59:49ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2025-01-011210.3389/fcell.2024.14838431483843Recent advances in the regulatory and non-coding RNA biology of osteogenic differentiation: biological functions and significance for bone healingSamaris ArangurenHisae ColeLauren Jeannette DarganMadison SarloSumin ChoiIsha SatapathyJaira Ferreira de VasconcellosInjuries associated with contemporary life, such as automobile crashes and sports injuries, can lead to large numbers of traumatic neuromuscular injuries that are intimately associated with bone fractures. Regulatory and non-coding RNAs play essential roles in multiple cellular processes, including osteogenic differentiation and bone healing. In this review, we discuss the most recent advances in our understanding of the regulatory and non-coding RNA biology of osteogenic differentiation in stem, stromal and progenitor cells. We focused on circular RNAs, small nucleolar RNAs and PIWI-interacting RNAs and comprehensively summarized their biological functions as well as discussed their significance for bone healing and tissue regeneration.https://www.frontiersin.org/articles/10.3389/fcell.2024.1483843/fullnon-coding RNAsregulatory RNAsosteogenic differentiationbone fracturebone healingcircular RNAs |
| spellingShingle | Samaris Aranguren Hisae Cole Lauren Jeannette Dargan Madison Sarlo Sumin Choi Isha Satapathy Jaira Ferreira de Vasconcellos Recent advances in the regulatory and non-coding RNA biology of osteogenic differentiation: biological functions and significance for bone healing Frontiers in Cell and Developmental Biology non-coding RNAs regulatory RNAs osteogenic differentiation bone fracture bone healing circular RNAs |
| title | Recent advances in the regulatory and non-coding RNA biology of osteogenic differentiation: biological functions and significance for bone healing |
| title_full | Recent advances in the regulatory and non-coding RNA biology of osteogenic differentiation: biological functions and significance for bone healing |
| title_fullStr | Recent advances in the regulatory and non-coding RNA biology of osteogenic differentiation: biological functions and significance for bone healing |
| title_full_unstemmed | Recent advances in the regulatory and non-coding RNA biology of osteogenic differentiation: biological functions and significance for bone healing |
| title_short | Recent advances in the regulatory and non-coding RNA biology of osteogenic differentiation: biological functions and significance for bone healing |
| title_sort | recent advances in the regulatory and non coding rna biology of osteogenic differentiation biological functions and significance for bone healing |
| topic | non-coding RNAs regulatory RNAs osteogenic differentiation bone fracture bone healing circular RNAs |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2024.1483843/full |
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