Slow and fast cortical cholinergic arousal is reduced in a mouse model of focal seizures with impaired consciousness

Slow and fast cortical cholinergic arousal is reduced in a mouse model of focal seizures with impaired consciousness

Summary: Patients with focal temporal lobe seizures often experience loss of consciousness associated with cortical slow waves, like those in deep sleep. Previous work in rat models suggests that decreased subcortical arousal causes depressed cortical function during focal seizures. However, these s...

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Main Authors: Lim-Anna Sieu, Shobhit Singla, Jiayang Liu, Xinyuan Zheng, Abdelrahman Sharafeldin, Ganesh Chandrasekaran, Marcus Valcarce-Aspegren, Ava Niknahad, Ivory Fu, Natnael Doilicho, Abhijeet Gummadavelli, Cian McCafferty, Richard B. Crouse, Quentin Perrenoud, Marina R. Picciotto, Jessica A. Cardin, Hal Blumenfeld
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Cell Reports
Subjects:
CP: Neuroscience
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124724013639
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